74590-69-5

Basic information

• Product Name: 4-chloro-α-fluorobenzeneacetic acid
• Synonyms: 4-chloro-α-fluorobenzeneacetic acid
• CAS NO: 74590-69-5
• Molecular Weight: 188.586
• Mol File: 74590-69-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 61-63 °C(Solv: hexane (110-54-3))
• Boiling Point: 303.5±27.0 °C(Predicted)
• Density: 1.396±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-chloro-α-fluorobenzeneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-α-fluorobenzeneacetic acid(74590-69-5)
• EPA Substance Registry System: 4-chloro-α-fluorobenzeneacetic acid(74590-69-5)

Safety Data

• Hazardous Substances Data: 74590-69-5(Hazardous Substances Data)

Upstream product

• 373-91-1 hypofluorous acid trifluoromethyl ester 
• 75581-01-0 4-(4-chlorobenzylidene)-2,2,6,6-tetramethyl-3,5-dioxa-2,6-disilaheptane 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 492-86-4 (R)-4-chloro-α-hydroxy-benzeneacetic acid 
• 171334-87-5 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-1-(4-nitro-phenyl)-ethyl ester 
• 171334-86-4 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-1-(4-methoxy-phenyl)-ethyl ester 
• 171334-35-3 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-2-methyl-1-phenyl-propyl ester 
• 171334-34-2 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (R)-2-methyl-1-phenyl-propyl ester 
• 171334-31-9 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-1-phenyl-ethyl ester 
• 171334-30-8 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (R)-1-phenyl-ethyl ester 

Relevant articles and documents

UTILISATION D'ACIDES 2-FLUORO ACETIQUES SUBSTITUES COMME AGENTS CHIRAUX DE DERIVATION

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Synthesis of α-fluorocarbonyl compounds

Process for preparing an organic compound of the formula R2 R2 CFC(O)R3, which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF and STR1 R is polyfluoroperhaloalkyl of 1-6 carbon atoms or FOCF2 ; R1 is hydrocarbyl of 1-6 carbon atoms; each R2 is selected from H, alkyl of 1-17 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl and such alkyl, cycloalkyl, aryl and heteroaryl substituted by halogen or alkoxy of 1-6 carbon atoms; R3 is selected from H, alkyl and haloalkyl of 1-16 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl and haloaryl, OSi(R1)3, OH, NH2, alkoxy of 1-6 carbon atoms, aryloxy, NHR1 and NR12 wherein R1 is alkyl of 1-6 carbon atoms, N-arylamino and nitrogen or sulfur heterocyclic of 4-5 carbon atoms; R3 and one R2 taken together is a diradical which with the C=C group is carbocyclic, heterocyclic or haloheterocyclic, and recovering from the reaction mixture the compound of the formula R2 R2 CFC(O)R3.