74611-53-3

Basic information

• Product Name: 2-(Butylamino)nicotinic acid
• Synonyms: 2-(Butylamino)nicotinic acid
• CAS NO: 74611-53-3
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194
• Mol File: 74611-53-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160-161 °C
• Boiling Point: 362.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.183±0.06 g/cm3(Predicted)
• PKA: 1.84±0.36(Predicted)
• CAS DataBase Reference: 2-(Butylamino)nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Butylamino)nicotinic acid(74611-53-3)
• EPA Substance Registry System: 2-(Butylamino)nicotinic acid(74611-53-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 74611-53-3(Hazardous Substances Data)

Usage

General Description

2-(Butylamino)nicotinic acid, also known as 2-butanamine nicotinic acid, is a chemical compound that belongs to the class of pyridine carboxylic acids. It consists of a nicotinic acid (or niacin) molecule with a butylamino group attached to the second position of the pyridine ring. 2-(Butylamino)nicotinic acid is of interest in pharmaceutical research due to its potential biological activities, including as a potential vasodilator and anti-inflammatory agent. It has also been studied for its potential role in treating cardiovascular diseases and metabolic disorders, as well as its potential to be used in the treatment of cancer. Further research is needed to fully understand the properties and potential applications of 2-(Butylamino)nicotinic acid.

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 109-73-9 N-butylamine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 74611-50-0 2-(butylamino)pyridine-3-carbonitrile 

Downstream Products

• 583031-56-5 1-butyl-4-chloro-1,8-naphthyridin-2(1H)-one 
• 476371-02-5 tert-butyl [4-({[(4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)amino]carbonyl}amino)-3,5-diisopropylphenyl]carbamate 
• 437763-93-4 tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate 
• 455288-42-3 {4-[3-(3-benzyloxy-propoxy)-phenyl]-1-butyl-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl}-carbamic acid phenyl ester 
• 259225-38-2 3-amino-4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-1,8-naphthyridin-2(1H)-one 

Relevant articles and documents

Synthesis of 2-(arylamino)nicotinic acids in high-temperature water

In hydrothermal reactions at 150-180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up to 98%). Springer Science+Business Media B.V. 2012.

Synthesis of SMP-797: A new potent ACAT inhibitor

A potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797 was effectively synthesized by the urea formation of 3-amino-4-aryl-1,8- naphthyridin-2(1H)-one and 4-amino-2,6-diisopropylamine. The synthesis of the former compound involved the Suzuki coupling reaction as a key step, and the latter was prepared by the 4-selective nitration of 2,6-diisopropylaniline using 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone.

Synthesis of new derivatives of 1H,3H-pyrido[2,3-d]pyrimidine-2,4-dione

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