7464-44-0

Basic information

• Product Name: 4-methoxy-N-(propan-2-yl)benzamide
• Synonyms: benzamide, 4-methoxy-N-(1-methylethyl)-; N-Isopropyl-4-methoxybenzamide
• CAS NO: 7464-44-0
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 7464-44-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 339.4°C at 760 mmHg
• Flash Point: 159.1°C
• Density: 1.032g/cm³
• Vapor Pressure: 9.19E-05mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: 4-methoxy-N-(propan-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-(propan-2-yl)benzamide(7464-44-0)
• EPA Substance Registry System: 4-methoxy-N-(propan-2-yl)benzamide(7464-44-0)

Safety Data

• Hazardous Substances Data: 7464-44-0(Hazardous Substances Data)

Usage

Description

4-methoxy-N-(propan-2-yl)benzamide is an organic compound with the molecular formula C12H17NO2. It is a benzamide derivative featuring a methoxy group and a propan-2-yl group attached to the benzene ring. This chemical is characterized by its potential to interact with biological systems, making it a candidate for use in the synthesis of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Synthesis:
4-methoxy-N-(propan-2-yl)benzamide is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the molecular structures of potential drugs.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-methoxy-N-(propan-2-yl)benzamide is used as a building block in the creation of compounds designed to protect crops and enhance agricultural productivity.
Used in Drug Discovery and Development:
4-methoxy-N-(propan-2-yl)benzamide is utilized as a chemical entity in drug discovery and development processes due to its potential to interact with biological targets, which may lead to the creation of new therapeutic agents.
Further research is necessary to fully understand the properties and potential uses of 4-methoxy-N-(propan-2-yl)benzamide, as its applications may expand with advancements in scientific understanding.

Upstream product

• 88229-13-4 N-cyclopropyl-4-methoxybenzamide 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 97661-70-6 4-methoxy-N-methyl-N-nitrosobenzamide 
• 75-31-0 isopropylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 937-29-1 4-methoxybenzoyl bromide 
• 79606-43-2 N,N-diisopropyl-4-methoxybenzamide 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 19172-47-5 Lawessons reagent 
• 846550-59-2 N-isopropyl-4-methoxybenzohydroxamic acid 

Downstream Products

• 1158371-11-9 [(4-methoxyphenyl)methyl](propan-2-yl)amine hydrochloride 
• 99334-60-8 1-(4-methoxylphenyl)-3-phenylbutan-1-one 
• 7469-80-9 cyclohexyl 4-methoxyphenyl ketone 
• 2040-20-2 4-methoxyisobutyrophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 13033-52-8 N-(2-propyl)-4-methoxybenzylideneamine 
• 70894-74-5 [(4-methoxyphenyl)methyl](propan-2-yl)amine 
• 874-90-8 4-methoxybenzonitrile 
• 1259161-63-1 C₁₁H₁₄ClNO₂ 
• 377726-66-4 C₁₁H₁₄ClNO 
• 127787-43-3 2-Formyl-N-isopropyl-4-methoxy-N-trimethylsilanylmethyl-benzamide 
• 62926-14-1 N-isopropyl-4-methoxythiobenzamide 

Relevant articles and documents

Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis

The metal-free catalytic hydrogenation of secondary carboxylic acid amides is developed. The reduction is realized by two new catalytic reactions. First, the amide is converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides are hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mechanical calculations support an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.

Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.

Tf2O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones

Based on the Tf2O-mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones has been developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 ? molecular sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis.