74654-05-0

Basic information

• Product Name: Methyl-PEG3-MS
• Synonyms: Methyl-PEG3-MS;m-PEG4-Ms;mPEG3-Methanesulfonate;Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]-, methanesulfonate;mPEG3-MS
• CAS NO: 74654-05-0
• Molecular Formula: C₈H₁₈O₆S
• Molecular Weight: 242.29
• Mol File: 74654-05-0.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 152 °C(Press: 0.01 Torr)
• Appearance: /
• Density: 1.170±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Methyl-PEG3-MS(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-PEG3-MS(74654-05-0)
• EPA Substance Registry System: Methyl-PEG3-MS(74654-05-0)

Safety Data

• Hazardous Substances Data: 74654-05-0(Hazardous Substances Data)

Usage

Description

Methyl-PEG3-MS, also known as m-PEG4-Ms, is a PEG (polyethylene glycol) linker containing a mesyl group. The mesyl group serves as an excellent leaving group for nucleophilic substitution reactions, while the hydrophilic PEG spacer enhances solubility in aqueous media. This unique structure makes Methyl-PEG3-MS a versatile molecule with potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
Methyl-PEG3-MS is used as a molecular linker for improving the solubility and bioavailability of drugs. The hydrophilic PEG spacer increases the drug's solubility in aqueous environments, while the mesyl group facilitates nucleophilic substitution reactions, allowing for the attachment of various drug molecules.
Used in Chemical Synthesis:
In the field of chemical synthesis, Methyl-PEG3-MS serves as a versatile building block for the creation of complex molecules. The mesyl group's reactivity as a leaving group enables the formation of new chemical bonds through nucleophilic substitution reactions, making it a valuable component in the synthesis of various compounds.
Used in Bioconjugation:
Methyl-PEG3-MS is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The PEG spacer provides a hydrophilic environment that can reduce aggregation and non-specific interactions, while the mesyl group allows for efficient coupling through nucleophilic substitution.
Used in Drug Delivery Systems:
In drug delivery systems, Methyl-PEG3-MS can be utilized as a component of targeted drug carriers. The PEG spacer can improve the solubility and circulation time of the drug in the body, while the mesyl group can be used to attach targeting ligands or other functional groups to enhance the specificity and efficacy of the drug delivery system.
Overall, Methyl-PEG3-MS is a multifunctional molecule with a wide range of applications in various industries, including pharmaceuticals, chemical synthesis, bioconjugation, and drug delivery systems. Its unique structure, combining a hydrophilic PEG spacer with a reactive mesyl group, makes it a valuable tool for improving solubility, bioavailability, and reactivity in a variety of contexts.

Upstream product

• 112-35-6 triethylene glucol monomethyl ether 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1352807-52-3 1-{2-[2-(2-methoxyethoxy)ethoxy]ethyl}-4-phenyl-1H-1,2,3-triazole 
• 1352807-63-6 1-{2-[2-(2-methoxyethoxy)ethoxy]ethyl}-3-methyl-4-phenyl-1H-1,2,3-triazol-3-ium iodide 
• 1352807-82-9 1-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-3-methyl-4-phenyl-1H-1,2,3-triazol-3-ium bis[(trifluoromethyl)sulfonyl]amide 
• 1367596-39-1 (4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-7-methoxy-9-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline trifluoroacetate 
• 1367594-59-9 (4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline 
• 72593-77-2 3,6,9-trioxadecyl bromide 
• 1059587-70-0 mPEG₃-N-diphenhydramine 
• 1059587-93-7 mPEG₃-NH-diphenhydramine 
• 1059588-35-0 mPEG₃-N-(diphenhydramine)2 
• 477775-57-8 20-methoxy-1-(methylsulfonyl)oxy-3,6,9,12,15,18-hexaoxaeicosane 
• 1354744-91-4 naloxegol oxalate 
• 854601-70-0 (5α,6α)-17-allyl-6-(2,5,8,11,14,17,20-heptaoxadocosan-22-yloxy)-4,5-epoxymorphinan-3,14-diol 
• 104518-25-4 22-bromo-2,5,8,11,14,17,20-heptaoxadocosane 
• 174485-20-2 2-Hydroxy-4-(2-(2-(2-methoxyethoxy)-ethoxy)-ethoxy)-acetophenone 

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