7466-32-2

Basic information

• Product Name: 6-chloro-2-phenyl-1,3-benzothiazole
• CAS NO: 7466-32-2
• Molecular Formula: C₁₃H₈ClNS
• Molecular Weight: 245.7273
• Mol File: 7466-32-2.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 389°C at 760 mmHg
• Flash Point: 189.1°C
• Density: 1.339g/cm³
• Vapor Pressure: 6.58E-06mmHg at 25°C
• Refractive Index: 1.689
• CAS DataBase Reference: 6-chloro-2-phenyl-1,3-benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-phenyl-1,3-benzothiazole(7466-32-2)
• EPA Substance Registry System: 6-chloro-2-phenyl-1,3-benzothiazole(7466-32-2)

Safety Data

• Hazardous Substances Data: 7466-32-2(Hazardous Substances Data)

Usage

General Description

6-chloro-2-phenyl-1,3-benzothiazole is a chemical compound with the molecular formula C13H8ClNS. It is a member of the benzothiazole family of compounds, which are known for their wide range of applications such as in pharmaceuticals, agrochemicals, and materials science. The presence of a chloro group and a phenyl group in the compound gives it unique chemical properties and potential biological activities. This chemical may be used in the development of new drugs or agrochemicals due to its structural characteristics and potential biological activities. Additionally, it may also have applications in materials science due to its potential for modifying the physical and chemical properties of certain materials.

Upstream product

• 3622-23-9 2,6-dichloro-1,3-benzothiazole 
• 98-80-6 phenylboronic acid 
• 23474-98-8 2-amino-5-chlorobenzenethiol 
• 614-16-4 Benzoylacetonitrile 
• 100-52-7 benzaldehyde 
• 5310-28-1 N-(4-chlorophenyl)thiobenzamide 
• 98-86-2 acetophenone 
• 2942-10-1 6-chloro-1,3-benzothiazole 
• 103-82-2 phenylacetic acid 
• 611-06-3 2,4-dichloronitrobenzene 
• 63069-48-7 p-chloro-o-iodoaniline 
• 100-53-8 phenylmethanethiol 
• 873-38-1 4-chloro-2-bromoaniline 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1379479-34-1 2-([1,1':3',1''-terphenyl]-2'-yl)-6-chlorobenzo[d]thiazole 
• 1379479-35-2 6-chloro-2-(4,4''-dichloro-[1,1':3',1''-terphenyl]-2'-yl)benzo[d]thiazole 
• 1379479-33-0 6-chloro-2-(4,4''-dimethyl-[1,1':3',1''-terphenyl]-2'-yl)benzo[d]thiazole 
• 1242288-73-8 6-chloro-2-(2-fluorophenyl)benzo[d]thiazole 
• 1242286-86-7 6-chloro-2-(2,6-difluorophenyl)benzo[d]thiazole 
• 1242288-47-6 2-(3-nitrophenyl)-6-chlorobenzothiazole 

Relevant articles and documents

A highly regioselective synthesis of 2-aryl-6-chlorobenzothiazoles employing microwave-promoted Suzuki-Miyaura coupling reaction

Suzuki-Miyaura coupling reactions of 2,6-dichlorobenzothiazole with arylboronic acids, promoted by microwave heating, efficiently produce 2-aryl-6-chlorobenzothiazoles in a highly regioselective manner. This process serves as the foundation for a simple m

Recyclable copper-catalyzed cyclization of o-haloanilides and metal sulfides: An efficient and practical access to substituted benzothiazoles

An efficient heterogeneous copper-catalyzed cyclization of o-haloanilides and metal sulfides has been achieved via the C–S coupling in DMF at 80 or 140 °C in the existence of an MCM-41-bound NHC-Cu(I) catalyst and then intramolecular condensation, delivering a wide range of substituted benzothiazoles in mostly good to high yields. This new MCM-41-NHC-CuI complex can facilely be obtained by a two-step procedure starting from easily accessible and inexpensive reagents and reused more than seven times without any significant loss of its catalytic efficiency. The present protocol has been successfully applied to the gram-scale synthesis of two antitumor agents 5F203 and PMX 610.

Photocatalyst- And Transition-Metal-Free Visible-Light-Promoted Intramolecular C(sp2)-S Formation

A photocatalyst- and transition-metal-free visible-light-induced cyclization of ortho-halothiobenzanilides has been developed. Upon irradiation with visible light, substrates undergo dehalogenative cyclization to 2-aryl benzothiazoles with high efficiency and selectivity. This photocyclization exhibits a high tolerance to various functional groups, is applicable for the synthesis of 2-alkyl benzothiazoles, and is easy to set up for gram-scale reaction.