7468-12-4

Basic information

• Product Name: 1,4-Diphenyl-3-methylazetidine-2-one
• Synonyms: 1,4-Diphenyl-3-methylazetidine-2-one;3-Methyl-1,4-diphenylazetidin-2-one
• CAS NO: 7468-12-4
• Molecular Formula: C₁₆H₁₅NO
• Molecular Weight: 237.2964
• Mol File: 7468-12-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 443.3°Cat760mmHg
• Flash Point: 215.1°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 4.71E-08mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 1,4-Diphenyl-3-methylazetidine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Diphenyl-3-methylazetidine-2-one(7468-12-4)
• EPA Substance Registry System: 1,4-Diphenyl-3-methylazetidine-2-one(7468-12-4)

Safety Data

• Hazardous Substances Data: 7468-12-4(Hazardous Substances Data)

Usage

Chemical class

Azetidines

Physical appearance

White crystalline powder

Uses

Antihistamine and anxiolytic medication

Mechanism of action

Blocks histamine receptors in the brain

Effects on symptoms

Reduces itching, sneezing, and runny nose

Additional effects

Sedative and anxiolytic properties

Treatment applications

Anxiety, tension, and other conditions involving histamine response

Side effects

Drowsiness and dizziness

Caution

Should be used with caution due to potential side effects

InChI:InChI=1/C16H15NO/c1-12-15(13-8-4-2-5-9-13)17(16(12)18)14-10-6-3-7-11-14/h2-12,15H,1H3

Upstream product

• 72658-03-8 (Z)-1-methoxy-1-(trimethylsiloxy)propene 
• 538-51-2 benzylidene phenylamine 
• 72658-09-4 (E)-(1-methoxyprop-1-enyloxy)trimethylsilane 
• 63584-42-9 {[(1E)-1-(ethylthio)prop-1-enyl]oxy}(trimethyl)silane 
• 63584-42-9 (Z)-1-ethylthio-1-(trimethylsiloxy)propene 
• 79-03-8 propionyl chloride 

Downstream Products

• 74632-70-5 3-Methyl-1,4-diphenyl-2-azetidinthion 

Relevant articles and documents

One-pot synthesis of β-lactams from aldimines and ketene silyl acetals by tandem lewis base-catalyzed Mannich-type addition and cyclization

An efficient method for one-pot synthesis of β-lactams from aldimines and ketene silyl acetals by tandem Lewis base-catalyzed Mannich-type addition and cyclization, namely reaction of benzylideneanilines and trimethylsilyl enolates derived from esters or thioesters was established by using a Lewis base catalyst such as lithium acetate, N-lithio-2-pyrrolidone, potassium salt of phthalimide or lithium methoxide in DMF at room temperature to afford the corresponding β-lactams in good to high yields with moderate trans-selectivities. Copyright

Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides

New conditions for the acid chloride-imine reaction of nonactivated alkyl acid chlorides provide 3-alkyl substituted β-lactams in good yields with high trans selectivity.