7469-49-0

Basic information

• Product Name: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate
• CAS NO: 7469-49-0
• Molecular Formula: C₁₇H₂₆N₂O₄
• Molecular Weight: 322.3993
• Mol File: 7469-49-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 370.4°C at 760 mmHg
• Flash Point: 177.8°C
• Density: 1.136g/cm³
• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate(7469-49-0)
• EPA Substance Registry System: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate(7469-49-0)

Safety Data

• Hazardous Substances Data: 7469-49-0(Hazardous Substances Data)

Upstream product

• 100616-00-0 (3-isocyanato-4-methyl-phenyl)-carbamic acid butyl ester 
• 71-36-3 butan-1-ol 
• 584-84-9 2,4-Toluene diisocyanate 
• 592-35-8 butyl carbamate 
• 95-80-7 4-methylbenzene-1,3-diamine 
• 124-38-9 carbon dioxide 
• 6935-99-5 2,4-bis(methoxycarbonylamino)toluene 
• 57-13-6 urea 

Downstream Products

• 584-84-9 2,4-Toluene diisocyanate 

Relevant articles and documents

Synthesis and antitussive activity of obtucarbamate A derivatives

Obtucarbamate A was purified from Disporum cantoniense with good antitussive property. In present work, a series of obtucarbamate A derivatives were designed and synthesized from obtucarbamate A by microwave method, and their antitussive activity were evaluated. The results showed that the toluene diisocyanate was obtained with a yield of 95.1percent using a simple method, 1-methyl-2-pyrrolidinone as solvent, temperature of 190 °C, microwave irradiation at 60 W power for 30 min. All compounds have good antitussive activity, and small steric hindrance unsaturated groups of ester chains and amino groups favor activity. It is the first reported of obtucarbamate A derivatives used as antitussive, and the results provide a basis for the application of obtucarbamate derivatives as new antitussive.

Halogen-Free Synthesis of Carbamates from CO2 and Amines Using Titanium Alkoxides

A direct synthesis of carbamates from amines and carbon dioxide in the presence of Ti(OR)4 (R=nBu (1), Me (2), Et (3), nPr (4)) was investigated. Aniline was reacted with titanium n-butoxide (1) in the presence of carbon dioxide (5 MPa) to give the corresponding n-butyl N-phenylcarbamate (BPC) in nearly quantitative yield (99 %) within 20 min. Furthermore, 1 could be regenerated upon reaction with n-butanol during water removal. The recovered 1 could then be reused in a subsequent reaction.

Insights into the organocatalyzed synthesis of urethanes in supercritical carbon dioxide: An in Situ FTIR spectroscopic kinetic study

The kinetics of urethane (carbamate) formation in supercritical CO 2 (scCO2) has been studied by in situ FTIR spectroscopy by using the reaction between n-butanol and toluene-2,4-diisocyanate as a model for the synthesis of polyureth