74704-03-3

Basic information

• Product Name: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-[(methylsulfonyl)oxy]-8-oxo-, diphenylmethyl ester, (6R,7R)-
• CAS NO: 74704-03-3
• Molecular Formula: C21H20N2O6S2
• Molecular Weight: 460.532
• Mol File: 74704-03-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-[(methylsulfonyl)oxy]-8-oxo-, diphenylmethyl ester, (6R,7R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-[(methylsulfonyl)oxy]-8-oxo-, diphenylmethyl ester, (6R,7R)-(74704-03-3)
• EPA Substance Registry System: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-[(methylsulfonyl)oxy]-8-oxo-, diphenylmethyl ester, (6R,7R)-(74704-03-3)

Safety Data

• Hazardous Substances Data: 74704-03-3(Hazardous Substances Data)

Downstream Products

• 454472-32-3 diphenylmethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-methanesulfonyloxy-3-cephem-4-carboxylate 
• 163009-37-8 diphenylmethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 288379-94-2 diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(3-pyridyl)thiomethylthio]-3-cephem-4-carboxylate 
• 163009-34-5 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[2-(4-pyridyl)ethylthio]-3-cephem-4-carboxylate 
• 288380-05-2 diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate 
• 288379-89-5 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-(4-pyridylthio)-3-cephem-4-carboxylate 
• 179034-72-1 benzhydryl 7β-[2-(phenylthio)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate 
• 454472-36-7 diphenylmethyl 7β-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-fluoroethoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 454472-34-5 diphenylmethyl 7β-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-(fluoromethoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 454472-35-6 diphenylmethyl 7β-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 454472-41-4 diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 454472-38-9 diphenylmethyl 7β-[(Z)-2-(2-formamidothiazol-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 454472-37-8 diphenylmethyl 7β-[(Z)-2-(2-formamidothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 454472-40-3 diphenylmethyl 7β-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(acetoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 

Relevant articles and documents

studies on anti-helicobacter pylori agents. Part 2: New cephem derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of cephem derivatives are described. Introduction of thio-heterocyclic groups containing N- and S-atoms to the 3-position and phenyl or thienyl acetamido groups to the 7-position of the cephem nucleus dramatically improved the activity. From this series of derivatives, compound 13i was found to have extremely potent in vitro anti-H. pylori activity, superior therapeutic efficacy compared to AMPC and CAM, no cross-resistance between CAM or MNZ and low potential for causing diarrhea due to instability to β-lactamase. Copyright (C) 2000 Elsevier Science Ltd.