7473-99-6

Basic information

• Product Name: 2-chloro-2-methylpropiophenone
• Synonyms: 2-chloro-2-methylpropiophenone;1-Propanone, 2-chloro-2-methyl-1-phenyl- (9CI);2-Chloro-2-methyl-1-phenyl-1-propanone
• CAS NO: 7473-99-6
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• EINECS: 231-273-6
• Product Categories: ACETYLHALIDE
• Mol File: 7473-99-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 252.7°C at 760 mmHg
• Flash Point: 132.4°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 0.0191mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 2-chloro-2-methylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-2-methylpropiophenone(7473-99-6)
• EPA Substance Registry System: 2-chloro-2-methylpropiophenone(7473-99-6)

Safety Data

• Hazardous Substances Data: 7473-99-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11ClO/c1-10(2,11)9(12)8-6-4-3-5-7-8/h3-7H,1-2H3

Upstream product

• 38744-73-9 2,2-dimethyl-3-phenyl-3-oxopropanoic acid 
• 13222-26-9 2-chloroisobutyryl chloride 
• 71-43-2 benzene 
• 10409-54-8 2-bromo-2-methyl-1-phenyl-propan-1-one 
• 538-93-2 1-phenyl-2-methylpropane 
• 26524-38-9 α-chloro-β,β-dimethylstyrene 
• 39753-69-0 2,2,5,5-tetramethyl-4-phenyl-3-imidazolin-1-oxyl 
• 21894-20-2 2-Chloro-3,3-dimethyl-2-phenyl-oxirane 
• 611-70-1 phenyl isopropyl ketone 

Downstream Products

• 16945-82-7 2-(4-hydroxy-5,5-dimethyl-4-phenyl-2-thioxo-thiazolidin-3-yl)-propionic acid 
• 16945-82-7 (S)-2-((Ξ)-4-hydroxy-5,5-dimethyl-4-phenyl-2-thioxo-thiazolidin-3-yl)-propionic acid 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 
• 59919-11-8 2-methyl-1-phenyl-2-(phenylthio)propan-1-one 
• 611-70-1 phenyl isopropyl ketone 
• 14225-56-0 α,α-dimethylphenacylthiol 
• 95249-25-5 2,2-dimethyl-3-(2-phenylethynyl)-3-phenyloxirane 
• 10409-55-9 (2-methyl-1-phenylprop-1-enyl) diethyl phosphate 
• 77006-52-1 (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride 
• 83846-34-8 2,2-Dimethyl-3-(1-methyl-1-nitro-ethyl)-3-phenyl-oxirane 
• 74074-84-3 α-(p-methylbenzenesulfonyl)isobutyrophenone 
• 95249-24-4 2,2-dimethyl-3-(1-pentynyl)-3-phenyloxirane 
• 25982-72-3 2-methyl-3-phenyl-but-3-en-2-ol 

Relevant articles and documents

Preparation method of photoinitiator

The invention discloses a preparation method of a photoinitiator. The preparation method comprises the following steps: acid chloride required for Fries reaction, aluminum trichloride and a solvent are mixed and then subjected to a Fourier reaction with benzene. Fries reaction intermediate purification method The Fourier reaction intermediate is mixed with chlorine for chlorination reaction, and the product of the chlorination reaction is subjected to gas-liquid separation to separate the gas. Reaction Section Step and The product purification step results in a photoinitiator finished product. To the technical scheme of the invention, the advantages of the traditional process of producing the photoinitiator are combined with the characteristics of the microchannel reactor to realize continuous preparation, the productivity can be improved, the production risk is reduced, the manpower and equipment investment are reduced, and the cost is further reduced.

Dichloromethane as a chlorination reagent for α-bromocarbonyl compounds in the presence of a copper catalyst

We found that dichloromethane is a powerful chlorinating reagent for the congested 3° and 2° Csp3Br bond of α-bromocarbonyl amides, esters, and ketones. In the presence of an appropriate copper complex as a catalyst, the desired chlorination occurred within an hour. Control experiments revealed that in situ-generated CuCl2 is a key chlorinating agent that reacts with the 3° or 2° alkyl radicals generated by the reaction between an α-bromocarbonyl compound and a Cu(I) salt.

2-hydroxy-2-methyl-1-phenyl-1-propyl ketone synthesis process

The present invention discloses a 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone synthesis process, which is characterized in that isobutyric acid is adopted as a raw material, an acylation reaction, a Friedel-Crafts reaction, and an alkaline hydrolysis reaction are performed to obtain a 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone crude product, and fine steaming is performed to obtain the 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone finished product. According to the present invention, the process is reasonable, no sulfur dioxide gas emits during the production process, the environmental pollution caused by the produced sodium chloride is low, and the product yield is high.