7474-64-8

Basic information

• Product Name: 2,3-diphenyl-2,3-dihydro-1H-inden-1-one
• Synonyms: 2,3-diphenyl-1-indanone
• CAS NO: 7474-64-8
• Molecular Formula: C₂₁H₁₆O
• Molecular Weight: 284.3511
• Mol File: 7474-64-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 401.7°C at 760 mmHg
• Flash Point: 173.8°C
• Density: 1.168g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 2,3-diphenyl-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenyl-2,3-dihydro-1H-inden-1-one(7474-64-8)
• EPA Substance Registry System: 2,3-diphenyl-2,3-dihydro-1H-inden-1-one(7474-64-8)

Safety Data

• Hazardous Substances Data: 7474-64-8(Hazardous Substances Data)

Usage

General Description

2,3-diphenyl-2,3-dihydro-1H-inden-1-one, also known as dihydroflavonol, is a chemical compound with the molecular formula C20H18O. It is a type of flavonoid, a class of plant secondary metabolites known for their antioxidant properties. Dihydroflavonol is commonly found in fruits, vegetables, and other plant-based foods, and has been shown to have potential health benefits due to its antioxidant and anti-inflammatory properties. It is being studied for its potential role in preventing and treating various diseases, including cancer, cardiovascular diseases, and age-related conditions. Dihydroflavonol has also shown promise as a natural food preservative and colorant due to its antioxidant and antimicrobial properties.

Upstream product

• 94880-38-3 2,3,3-triphenyl-propionyl chloride 
• 32141-20-1 methyl(1,2,3-triphenyl-1-cyclopropen-3-yl)ether 
• 501-65-5 diphenyl acetylene 
• 60-29-7 diethyl ether 
• 1801-42-9 2,3-diphenyl-1H-inden-1-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 53347-50-5 2,3-diphenyl-1H-inden-1-ol 
• 108-86-1 bromobenzene 
• 16618-72-7 3-phenyl-1-indanone 
• 100-52-7 benzaldehyde 
• 4023-77-2 1-benzoyl-1,2-diphenylethylene 
• 7474-65-9 (E)-2-phenylchalcone 
• 52095-44-0 (E)-2-styrylbenzaldehyde 
• 100-42-5 styrene 

Downstream Products

• 38274-35-0 1,2,3-triphenylindene 
• 797-98-8 2,3-diphenyl-2,3-epoxy-1-indanone 
• 89619-33-0 1-ethyl-2,3-diphenylindene 
• 89619-34-1 3-(1-methylethyl)-1,2-diphenylindene 
• 89619-35-2 1-tert-butyl-2,3-diphenylindene 
• 18636-54-9 1,2-diphenyl-1H-indene 
• 1801-42-9 2,3-diphenyl-1H-inden-1-one 
• 51944-58-2 2,3-diphenyl-1-p-tolyl-inden-1-ol 
• 70550-46-8 trans, cis-1,2,3-triphenylindane 

Relevant articles and documents

Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy

An unprecedented nickel-catalyzed domino reductive cyclization of alkynes and o-bromoaryl aldehydes is described. The reaction features broad substrate scope and is tolerant of a variety of functional groups, providing straightforward access to biologically significant indanones and spiroindanone pyrrolidine derivatives in good yields with excellent regio- and diastereoselectivity. Preliminary mechanistic studies have shown that indanones are formed by the cyclization of o-bromoaryl aldehydes and alkynes to form indenol intermediates, followed by hydrogen autotransfer.

Construction of Halofunctionalized Indenes via a Cascade Prins-Nazarov Cyclization Promoted by Dual Roles of BX3

Halofunctionalization of various unactivated arylalkynes to the corresponding 1H-indenes in the presence of a particular class of carboxaldehydes and boron trihalides (BX3, X=F, Cl, Br, I) is described. A diverse array of halofunctionalized indenes substituted with a heterocycle has been synthesized regioselectively with BX3 as a promotor for the carbocyclization and a source of X? for halogenation. This reaction proceeds via a formal halogenative [4+1] cycloaddition between arylalkynes and carboxaldehydes promoted by boron trihalides to generate halofunctionalized indenes. The usefulness of the halofunctionalized indenes was demonstrated by their conversion to other derivatives via coupling, nucleophilic substitution, and oxidation. (Figure presented.).

Preparation method of 3-aryl-1-indanone derivate

The invention discloses a preparation method of a 3-aryl-1-indanone derivate. The structural formula of the 3-aryl-1-indanone derivate is shown in the formula III. The preparation method comprises the following steps that a compound shown in the formula I reacts with a compound shown in the formula II in the presence of methyl trifluoromethanesulfonate, and therefore the 3-aryl-1-indanone derivate shown in the formula III is obtained. The preparation method of the 3-aryl-1-indanone derivate is scientific and reasonable, 3-aryl-1-indanone derivates with various substituent groups can be obtained, the raw materials are easy to obtain, no metal participates in the reaction, reaction atoms are economical, and meanwhile the preparation method has the advantages that operation is simple and convenient, the synthesis productive rate is high, the product is easy to purify, and environmental protection is achieved.