747414-16-0

Basic information

• Product Name: Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-
• Synonyms: Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-;(4-(prop-1-en-2-yl)-1,3-phenylene)bis(oxy)bis(Methylene)dibenzene;2,4-bis(benzyloxy)-1-(prop-1-en-2-yl)benzene;1-(1-Methylethenyl)-2,4-bis(phenylmethoxy)Benzene;2,4-bis(benzyloxy)-1-isopropenylbenzene
• CAS NO: 747414-16-0
• Molecular Formula: C₂₃H₂₂O₂
• Molecular Weight: 330.41958
• Mol File: 747414-16-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-(747414-16-0)
• EPA Substance Registry System: Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-(747414-16-0)

Safety Data

• Hazardous Substances Data: 747414-16-0(Hazardous Substances Data)

Usage

General Description

Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylmethoxy)- is a chemical compound with the molecular formula C26H24O2. It is a member of the benzene family and is commonly used in the production of various industrial products such as plastics, resins, and synthetic fibers. Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)- is known for its aromatic and flammable properties and is considered to be a potentially hazardous material. It is important for individuals working with this compound to take necessary safety precautions to avoid any potential health risks associated with its use.

Upstream product

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Downstream Products

• 23504-03-2 2,4-dihydroxy-1-isopropylbenzene 
• 1581709-34-3 4-(4-{p-[(4-phenyl-1-piperazinyl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)-1,3-cumenediol 
• 1581709-46-7 C₃₀H₄₁N₅O₄ 
• 1383717-51-8 1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid cyclopentylamide 
• 1383717-52-9 1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid cyclohexylamide 
• 1383717-53-0 [1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazol-4-yl]morpholin-4-ylmethanone 
• 1383717-54-1 (S)-2-{[1-(2,4-dihydroxy-5-isopropylphenyl)-5-(4-morpholin-4-ylmethylphenyl)-1H-[1,2,3]triazole-4-carbonyl]amino}-3-methylbutyric acid 
• 1581709-47-8 C₃₀H₄₀N₆O₆ 
• 1581709-48-9 C₂₉H₃₅N₅O₆ 
• 1581709-50-3 C₃₁H₄₁N₅O₆ 
• 1581709-36-5 4-(4-{p-[(4-benzyl-1-piperazinyl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)-1,3-cumenediol 
• 1383717-86-9 1-{4-[3-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-benzyl}-4-phenyl-piperazine 
• 1383717-85-8 1-benzyl-4-{4-[3-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-benzyl}-piperazine 
• 1383717-83-6 4-{4-[3-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-benzyl}-morpholine 

Relevant articles and documents

Design and Synthesis of Hsp90 Inhibitors with B-Raf and PDHK1 Multi-Target Activity

The design of multi-target ligands has become an innovative approach for the identification of effective therapeutic treatments against complex diseases, such as cancer. Recent studies have demonstrated that the combined inhibition of Hsp90 and B-Raf provides synergistic effects against several types of cancers. Moreover, it has been reported that PDHK1, which presents an ATP-binding pocket similar to that of Hsp90, plays an important role in tumor initiation, maintenance and progression, participating also to the senescence process induced by B-Raf oncogenic proteins. Based on these premises, the simultaneous inhibition of these targets may provide several benefits for the treatment of cancer. In this work, we set up a design strategy including the assembly and integration of molecular fragments known to be important for binding to the Hsp90, PDHK1 and B-Raf targets, aided by molecular docking for the selection of a set of compounds potentially able to exert Hsp90-B-Raf-PDHK1 multi-target activities. The designed compounds were synthesized and experimentally validated in vitro. According to the in vitro assays, compounds 4 a, 4 d and 4 e potently inhibited Hsp90 and moderately inhibited the PDHK1 kinase. Finally, molecular dynamics simulations were performed to provide further insights into the structural basis of their multi-target activity.

Phenyl 1, 2 - isoxazole or phenyl 1, 2 - pyrazole compound and use thereof (by machine translation)

The invention discloses the following formula of phenyl 1, 2 - different oxazole or 1, 2 - pyrazole compounds with use. Through the biological activity tests show that, the compound inhibiting heat shock protein 90 activity. Therefore, the invention phenyl 1, 2 - different oxazole or 1, 2 - pyrazole compounds can be used as a heat shock protein 90 inhibitor for the treatment of cancer. (by machine translation)

Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors

Abstract A series of 3,5-disubstitute-4-alkynylisoxazole derivatives were designed and synthesized through palladium(II)-copper(I) catalyzed Sonogashira cross-coupling reaction of an alkynyl moiety and an isoxazole scaffold as novel HSP90 inhibitors. The resultant compounds displayed moderate to potent binding affinity to HSP90 proteins, and also demonstrated good cell growth inhibitory activity against various cancer cell lines (A549, K562, MCF-7, DU145 and Hela). Some compounds (18d, 18e, 19a, 19d, 20c and 20q) show similar or better binding affinity towards HSP90α and HSP90β comparing to NVP-AUY922. In addition, compounds 18e, 19a and 20q exhibited potent inhibitory activity against various human cancer cell lines.