74754-99-7

Basic information

• Product Name: N-methoxy-1-tosylmethanimidoyl cyanide
• Synonyms: N-methoxy-1-tosylmethanimidoyl cyanide
• CAS NO: 74754-99-7
• Molecular Weight: 238.267
• Mol File: 74754-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methoxy-1-tosylmethanimidoyl cyanide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxy-1-tosylmethanimidoyl cyanide(74754-99-7)
• EPA Substance Registry System: N-methoxy-1-tosylmethanimidoyl cyanide(74754-99-7)

Safety Data

• Hazardous Substances Data: 74754-99-7(Hazardous Substances Data)

Upstream product

• 5697-44-9 p-tolylsulfonylmethyl isocyanide 
• 175201-58-8 C₉H₈N₂O₃S 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Relevant articles and documents

Free-radical carbo-oximation of olefins and subsequent radical-ionic cascades

A sequential carbo-formylation cascade has been developed, involving a free-radical carbo-oximation process, followed by the hydrolysis of the oxime ether. For this purpose, we designed a new SEM O-protected sulfonyl oxime, which enable both rapid radical addition and hydrolysis under mild conditions. The resulting aldehyde-esters were then engaged in various nucleophilic cascades, such as Sakurai allylations or domino-Mukaiyama aldol condensation/ lactonizations. Addition of an amine and TMSCN similarly led after Strecker reaction/lactamization to α-cyano-piperidinones in good overall yield. Finally, a Pictet-Spengler/lactamization sequence was devised, which open a new entry toward the tricyclic core of eburnan alkaloids.