74764-52-6

Basic information

• Product Name: 1,2-Di(2-pyridyl)benzene
• Synonyms: 1,2-Di(2-pyridyl)benzene;2,2'-(1,2-Phenylene)bispyridine;2,2'-o-Phenylenebispyridine
• CAS NO: 74764-52-6
• Molecular Formula: C₁₆H₁₂N₂
• Molecular Weight: 232.28
• Mol File: 74764-52-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Di(2-pyridyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Di(2-pyridyl)benzene(74764-52-6)
• EPA Substance Registry System: 1,2-Di(2-pyridyl)benzene(74764-52-6)

Safety Data

• Hazardous Substances Data: 74764-52-6(Hazardous Substances Data)

Usage

General Description

1,2-Di(2-pyridyl)benzene, also known as Bipyridyl, is a chemical compound with the molecular formula C18H12N2. It is a polycyclic aromatic hydrocarbon that consists of a benzene ring linked to two pyridine rings. 1,2-Di(2-pyridyl)benzene is commonly used as a ligand in coordination chemistry and is known for its ability to complex with metal ions, particularly transition metals. It is often used in the synthesis of coordination polymers and metal-organic frameworks due to its strong binding affinity for metal ions. Additionally, 1,2-Di(2-pyridyl)benzene has been studied for its potential applications in organic light-emitting diodes and other optoelectronic devices due to its fluorescent properties. However, it is important to handle this compound with caution as it is considered to be toxic and may pose risks to human health and the environment.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 1008-89-5 2-phenylpyridine 
• 134542-02-2 (E)-2-(buta-1,3-dien-1-yl)pyridine 
• 40086-66-6 2-Bromoacetylpyridine 
• 5029-67-4 2-iodopyridine 
• 109-09-1 2-chloropyridine 
• 28790-65-0 1,2-bis(2-pyridyl)acetylene 
• 504-31-4 pyran-2-one 

Relevant articles and documents

Ruthenium complex-catalyzed direct ortho arylation and alkenylation of 2-arylpyridines with organic halides

(Equation presented) The ortho position of the aromatic ring of pyridyl group-substituted aromatic compounds is directly arylated or alkenylated with organic halides in the presence of a catalytic amount of a ruthenium(II)-phosphine complex.

Ruthenium-Catalyzed C-H Bond Activation/Arylation Accelerated by Biomass-Derived Ligands

A variety of ligands are being explored extensively to achieve enhanced performance for ligand assisted C-H bond activation/functionalization reactions. We explored here several readily available biomass-derived ligands as effective additives to significantly enhance the catalytic activity of arene-Ru(II) dimer for ortho C-H bond arylation in a water-based catalytic reaction. We achieved almost 7-fold enhancement in the catalytic activity with [(η6-p-cymene)RuCl2]2 catalyst in the presence of levulinic acid ligand at 80 °C. Mass investigations revealed the in-situ formation of a ruthenium-levulinate complex, which presumably plays a crucial role in the formation of the important cycloruthenated intermediate by facilitating the initial activation of ortho C-H bond of 2-phenylpyridine. Density functional theoretical studies also inferred that the ligand assisted route is energetically more favorable, where the acetyl group is found to be involved in the deprotonation step.

Ruthenium(II)-Catalyzed Microwave-Promoted Multiple C-H Activation in Synthesis of Hexa(heteroaryl)benzenes in Water

A series of hexa(heteroaryl)benzenes were synthesized by the Ru(II)-carboxylate-catalyzed multiple C-H activation of benzenes carrying pyridyl, pyrimidyl, or pyrazolyl directing groups using N-heteroaryl bromides as coupling partners. The reactions procee