7477-66-9

Basic information

• Product Name: (2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride
• CAS NO: 7477-66-9
• Molecular Formula: C₁₀H₆BrClO₂
• Molecular Weight: 273.5104
• Mol File: 7477-66-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 354.1°C at 760 mmHg
• Flash Point: 168°C
• Density: 1.587g/cm³
• Vapor Pressure: 3.42E-05mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: (2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride(7477-66-9)
• EPA Substance Registry System: (2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride(7477-66-9)

Safety Data

• Hazardous Substances Data: 7477-66-9(Hazardous Substances Data)

Usage

Description

(2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride is a chemical compound with the molecular formula C10H7BrO2Cl. It is a derivative of butan-2-one and is an acyl chloride, containing a chloride group attached to the acyl function. (2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride features a butenoyl group, a bromophenyl group, and a carbonyl group, making it a versatile building block for the synthesis of more complex molecules. Due to its high reactivity, it should be handled with care in laboratory settings.

Uses

Used in Pharmaceutical Industry:
(2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride is used as a reagent for the preparation of various pharmaceuticals. Its unique structure allows for the introduction of butenoyl, bromophenyl, and carbonyl functionalities into more complex molecules, which can be crucial for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, (2E)-4-(4-bromophenyl)-4-oxobut-2-enoyl chloride is utilized as a reagent for the synthesis of various agrochemicals. Its ability to contribute specific functional groups to the molecules makes it valuable in the creation of pesticides, herbicides, and other agricultural chemicals that can effectively control pests and improve crop yields.

Upstream product

• 108-86-1 bromobenzene 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 

Downstream Products

• 78842-66-7 4-oxo-4-(4-bromo-phenyl)-trans-crotonic acid anilide 
• 30913-86-1 4-(4-bromo-phenyl)-4-oxo-butyric acid methyl ester 
• 851108-42-4 4-(4-bromophenyl)-4-oxobutanamide 
• 878654-34-3 4-oxo-4-(4-bromo-phenyl)-cis-crotonic acid dimethylamide 
• 90766-44-2 4-oxo-4-(4-bromo-phenyl)-cis-crotonic acid amide 
• 32095-83-3 4-oxo-4-(4-bromo-phenyl)-cis-crotonic acid methyl ester 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 879125-58-3 (E)-4-(4-bromophenyl)-N,N-dimethyl-4-oxobut-2-enamide 
• 108368-56-5 1-(4-bromo-phenyl)-4-(2.4.6-trimethyl-phenyl)-butene-(2t)-dione-(1.4) 
• 90766-44-2 (E)-4-oxo-4-(4-bromophenyl)-2-butenamide 
• 32149-27-2 trans-methyl-4-(4-bromophenyl)-4-oxobut-2-enoate 

Relevant articles and documents

(E)-4-Aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: Design, antiproliferative activity and inhibition of tubulin polymerization

Antiproliferative activity of twenty-nine (E)-4-aryl-4-oxo-2-butenoic acid amides against three human tumor cell lines (HeLa, FemX, and K562) is reported. Compounds showed antiproliferative activity in one-digit micromolar to submicromolar concentrations.