74787-38-5Relevant articles and documents
Synthesis of 5-[4,5-13C2]- and 5-[1,5-13C2]aminolevulinic acid
Iida, Katsumi,Tokiwa, Shinji,Ishii, Toshihiro,Kajiwara, Masahiro
, p. 569 - 576 (2007/10/03)
5-[4,5-13C2]- and 5-[1,5-13C2]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo [1,2-13C2]acetate (derived from [1,2-13C2]acetic acid) or ethyl bromo[2-13C]-acetate (derived from sodium [2-13C]acetate), followed by conversion to the chloride, coupling reaction with 2-ethoxycarbonylethylzinc iodide derived from ethyl 3-iodopropionate or 2-methoxy[13C]carbonylethylzinc iodide derived from methyl 3-iodo[1-13C]propionate (generated from potassium [13C]cyanide), and hydrolysis. Copyright