74788-46-8

Basic information

• Product Name: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE
• Synonyms: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE;1-(4-chlorophenyl)propan-1-amine(SALTDATA: FREE);1-(4-chlorophenyl)propylamine
• CAS NO: 74788-46-8
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 169.65128
• Mol File: 74788-46-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 67-68 °C
• Boiling Point: 244.317°C at 760 mmHg
• Flash Point: 117.062°C
• Appearance: /
• Density: 1.094g/cm³
• Vapor Pressure: 0.031mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.13±0.10(Predicted)
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE(74788-46-8)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE(74788-46-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 74788-46-8(Hazardous Substances Data)

Usage

Description

1-(4-chlorophenyl)propan-1-amine, commonly known as para-Chloroamphetamine (PCA), is a chemical compound with the molecular formula C9H12ClN. It is a derivative of amphetamine and exhibits psychoactive properties with stimulant effects on the central nervous system. PCA has been utilized in scientific research to investigate the neurochemistry and pharmacology of neurotransmitters like serotonin and dopamine. However, it is also recognized for its potential neurotoxic effects and is regulated as a controlled substance in many countries due to its potential for abuse.

Uses

Used in Scientific Research:
1-(4-chlorophenyl)propan-1-amine is used as a research chemical for studying the neurochemistry and pharmacology of neurotransmitters such as serotonin and dopamine. Its psychoactive properties allow researchers to gain insights into the mechanisms of action and interactions of these neurotransmitters within the central nervous system.
Used in Neurotransmitter Studies:
PCA is used as a tool in neurotransmitter studies to understand the effects of psychoactive substances on the brain's chemical messengers. This helps in the development of treatments for various neurological and psychiatric disorders.
Used in Toxicology Research:
Due to its potential neurotoxic effects, 1-(4-chlorophenyl)propan-1-amine is utilized in toxicology research to explore the impact of psychoactive substances on brain health and to develop strategies for mitigating their harmful effects.
Used in Regulatory and Forensic Analysis:
As a controlled substance with abuse potential, para-Chloroamphetamine is used in regulatory and forensic analysis to detect and monitor its presence in cases of substance abuse or illegal distribution. This aids in enforcing laws and regulations related to controlled substances.

InChI:InChI=1/C9H12ClN/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6,9H,2,11H2,1H3

Upstream product

• 6285-05-8 4'-chloropropiophenone 
• 540-69-2 ammonium formate 
• 925-90-6 ethylmagnesium bromide 
• 85654-07-5 N-(4-chlorobenzylidene)-N-(1,1,1-trimethylsilyl)amine 
• 56962-09-5 1-(4-chlorophenyl)-N-hydroxypropan-1-imine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1143532-27-7 4-amino-N-(1-(4-chlorophenyl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 132361-85-4 (Z)-3-[1-(4-Chloro-phenyl)-propylamino]-but-2-enoic acid methylamide 
• 74787-93-2 3-[1-(4-Chloro-phenyl)-propyl]-1-(2-hydroxy-ethyl)-1-methyl-thiourea 

Relevant articles and documents

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase

Chiral resolutions of trifluoroacetyl-derivatized 1-phenylalkylamines with different type and position of substituent were investigated by capillary gas chromatography by using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin diluted in OV-1701 as a chiral stationary phase. The influence of column temperature on retention and enantioselectivity was examined. All enantiomers of meta-substituted analytes as well as fluoro-substituted analytes could be resolved. Temperature had a favorable influence on enantioselectivity for small amines with substituents at the ortho-position. The type of substituent at the stereogenic center of amines also had a crucial effect as the ethyl group led to poor enantioseparation. Among all analytes studied, trifluoroacetyl-derivatized 1-(2′-fluorophenyl)ethylamine exhibited baseline resolution with the shortest analysis time.

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.