74830-47-0

Basic information

• Product Name: 2-bromobicyclo[2.2.1]heptane-1-carboxylic acid
• Synonyms: bicyclo[2.2.1]heptane-1-carboxylic acid, 2-bromo-
• CAS NO: 74830-47-0
• Molecular Formula: C₈H₁₁BrO₂
• Molecular Weight: 219.0757
• Mol File: 74830-47-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 314.1°C at 760 mmHg
• Flash Point: 143.8°C
• Density: 1.73g/cm³
• Vapor Pressure: 0.000103mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 2-bromobicyclo[2.2.1]heptane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromobicyclo[2.2.1]heptane-1-carboxylic acid(74830-47-0)
• EPA Substance Registry System: 2-bromobicyclo[2.2.1]heptane-1-carboxylic acid(74830-47-0)

Safety Data

• Hazardous Substances Data: 74830-47-0(Hazardous Substances Data)

Upstream product

• 2534-71-6 (+/-)-2-bromo-norbornane-2endo-carboxylic acid 
• 934-28-1 norbornane-2-carboxylic acid 
• 1755-01-7 endo-Dicyclopentadien 
• 61242-71-5 (1R,2S,4S)-Bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester 
• 51789-95-8 bicyclo[2.2.1]hept-5-ene-endo-2-carboxylic acid ethyl ester 
• 19926-90-0 (+/-)-endo-bicyclo[2.2.1]hept-5-ene-2-carbaldehyde 
• 3574-54-7 2-endo-Bicyclo<2.2.1>heptanecarboxaldehyde 
• 18720-30-4 norbornane-1-carboxylic acid 
• 934-29-2 acide bicyclo<2.2.1>heptane carboxylique-2 exo 
• 934-28-1 bicyclo(2.2.1)heptane-2-endo-carboxylic acid 
• 100379-07-5 2-exo-Bromobicyclo<2.2.1>heptane-2-endo-carboxaldehyde 

Downstream Products

• 41248-20-8 (+/-)-2-hydroxy-norbornane-2endo-carboxylic acid 
• 104085-12-3 (1S,2S,4R)-2-Bromo-bicyclo[2.2.1]heptane-1-carboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide 
• 104085-11-2 (1R,2R,4S)-2-Bromo-bicyclo[2.2.1]heptane-1-carboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide 
• 42409-28-9 trans-N-tert-Butyl-N'-1-norbornyldiazene 
• 107454-75-1 cis-N-(1-bicyclo<2.2.1>heptyl)-N'-(1-adamantyl)diazene 
• 126112-72-9 cis-N-tert-Butyl-N'-1-norbornyldiazene 
• 21245-51-2 1-norbornylamine 
• 78497-37-7 trans-N,N'-bis(bicyclo<2.2.2>oct-1-yl)diazene 
• 1193-43-7 1-bicyclo<2.2.2>octylammonium chloride 
• 2287-57-2 methyl bicyclo<2.2.1>heptane-1-carboxylate 
• 279-23-2 norbornene 
• 2534-77-2 exo-2-bromonorbornane 
• 149891-94-1 bicyclo<2.2.2>octane-1-carboxaldehyde-d tosylhydrazone 
• 7363-97-5 bicyclo<2.2.2>octane-1-carboxaldehyde tosylhydrazone 

Relevant articles and documents

CARBOCYCLIC PROLINAMIDE DERIVATIVES

This invention is directed to novel carbocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus

A synthetic route toward a series of unique cyclic nucleoside phosphonates locked in South conformation is described. The desired conformation is stabilized by a substitution of the sugar moiety by bicyclo[2.2.1]heptane (norbornane) bearing a purine or pyrimidine nucleobase in the bridgehead position. Although the final phosphonate derivatives are devoid of any significant antiviral activity probably due to the unfavorable conformational properties, several intermediates and their analogs exhibit surprising activity against feline herpes virus. Since these compounds do not possess an appropriate hydroxymethyl function allowing phosphorylation and subsequent incorporation into the polynucleotide chain, it seems to be likely that these compounds act by a novel unknown mechanism of action and may represent a new possible alternative for nucleoside and nucleotide therapeutics of this widely spread feline infection. A number of derivatives exerted also a significant antiviral activity against Coxsackievirus B3 and B4.

cis-Diazenes. Viscosity Effects, One-Bond Scission, and Cis-Trans Isomerization

Effects of solvent viscosity on the rates of overall thermal decomposition, deazatization, and iomerization of several symmetric and unsymmetric cis-diazenes (cis-azoalkanes) have been determined in pure alkanes and mixtures of octane and mineral oil.Increasing viscosity decreases the overall decomposition and deazatization rates for all of these cis-diazenes.While isomerization rates also decrease with increasing viscosity for most of the diazenes, that for cis-N-tert-butyl-N'-1-norbornyldiazene (1) increases.These results are interpreted in terms of deazatization via one-bond scission and an intermediate diazenyl radical, isomerization via nonradical inversion, and the possibility of isomerization via a diazenyl radical for 1.