748777-31-3

Basic information

• Product Name: Propanamide, 3,3'-dithiobis[N-[4-(trifluoromethyl)phenyl]-
• CAS NO: 748777-31-3
• Molecular Formula: C20H18F6N2O2S2
• Molecular Weight: 496.498
• Mol File: 748777-31-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanamide, 3,3'-dithiobis[N-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 3,3'-dithiobis[N-[4-(trifluoromethyl)phenyl]-(748777-31-3)
• EPA Substance Registry System: Propanamide, 3,3'-dithiobis[N-[4-(trifluoromethyl)phenyl]-(748777-31-3)

Safety Data

• Hazardous Substances Data: 748777-31-3(Hazardous Substances Data)

Upstream product

• 1119-62-6 3,3'-dithiobis(propionic acid) 
• 455-14-1 4-trifluoromethylphenylamine 
• 1002-18-2 3-(2-chlorocarbonyl-ethyldisulfanyl)-propionyl chloride 

Relevant articles and documents

Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones

The synthesis and antibacterial activity of several new 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-ones 8 and analogous 2-(4-substituted phenyl)-3(2H)-isothiazolones 3 and 4 substituted at 4 and/or 3-positions of the phenyl moiety with different groups of which some have shown to increase the antibacterial activity of both 3-aryl-2-oxazolidinones and 3(2H)-isothiazolones is described. The most active compounds were isothiazolyl oxazolidinones 8a,j with unsubstituted and 8b with 4-F substituted phenyl rings which showed activities higher than analogous 3(2H)-isothiazolones and comparable or superior to linezolid, vancomycin, and ciprofloxacin against some tested microorganisms. The change in position of F and/or the use of larger substituents gave compounds with reduced or no activity. Evaluation of cytotoxicity to mouse fibroblast (NIH/3T3) cells indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations.