748812-27-3

Basic information

• Product Name: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-
• CAS NO: 748812-27-3
• Molecular Formula: C19H14O2
• Molecular Weight: 274.319
• Mol File: 748812-27-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-(748812-27-3)
• EPA Substance Registry System: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-(748812-27-3)

Safety Data

• Hazardous Substances Data: 748812-27-3(Hazardous Substances Data)

Upstream product

• 90-15-3 α-naphthol 
• 60179-48-8 Malonsaeure-mono-α-naphthylester 
• 100-52-7 benzaldehyde 
• 140-10-3 (E)-3-phenylacrylic acid 

Downstream Products

• 6051-86-1 2-phenyl-2H-benzo[h]chromen-4(3H)-one 

Relevant articles and documents

Multifunctional cinnamic acid derivatives

Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino) ethan-1-ol. The synthesized molecules were evaluated as trypsin, lipoxygenase and lipid peroxidation inhibitors and for their cytotoxicity. Compound 2b derived from phenoxyphenyl cinnamic acid and propranolol showed the highest lipoxygenase (LOX) inhibition (IC50 = 6 uM) and antiproteolytic activity (IC50 = 0.425 uM). The conjugate 1a of simple cinnamic acid with propranolol showed the higher antiproteolytic activity (IC50 = 0.315 uM) and good LOX inhibitory activity (IC50 = 66 uM). Compounds 3a and 3b, derived from methoxylated caffeic acid present a promising combination of in vitro inhibitory and antioxidative activities. The S isomer of 2b also presented an interesting multitarget biological profile in vitro. Molecular docking studies point to the fact that the theoretical results for LOX-inhibitor binding are identical to those from preliminary in vitro study.