749230-37-3

Basic information

• Product Name: 3,6-DIFLUORO-2-HYDROXYBENZOIC ACID
• Synonyms: 3,6-DIFLUORO-2-HYDROXYBENZOIC ACID;3,6-Difluorosalicylic acid, 2-Carboxy-3,6-difluorophenol
• CAS NO: 749230-37-3
• Molecular Formula: C7H4F2O3
• Molecular Weight: 174.1
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 749230-37-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 269.3°C at 760 mmHg
• Flash Point: 116.7°C
• Appearance: /
• Density: 1.6g/cm³
• Vapor Pressure: 0.0036mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3,6-DIFLUORO-2-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-DIFLUORO-2-HYDROXYBENZOIC ACID(749230-37-3)
• EPA Substance Registry System: 3,6-DIFLUORO-2-HYDROXYBENZOIC ACID(749230-37-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 749230-37-3(Hazardous Substances Data)

Usage

Description

3,6-DIFLUORO-2-HYDROXYBENZOIC ACID is a chemical compound with the molecular formula C7H4F2O3. It is a derivative of benzoic acid, containing two fluorine atoms and a hydroxyl group attached to the benzene ring. This white crystalline solid is characterized by a melting point of around 161-163°C and is soluble in most organic solvents such as ethanol, acetone, and dimethyl sulfoxide.

Uses

Used in Pharmaceutical Industry:
3,6-DIFLUORO-2-HYDROXYBENZOIC ACID is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs with improved properties.
Used in Dye Industry:
In the dye industry, 3,6-DIFLUORO-2-HYDROXYBENZOIC ACID is used as a building block for the synthesis of dyes, enhancing the color and performance of various dye products.
Used in Organic Chemical Synthesis:
3,6-DIFLUORO-2-HYDROXYBENZOIC ACID is utilized as a reagent in various chemical reactions, facilitating the synthesis of a range of organic chemicals.
Used as a Precursor in Fluorinated Organic Compounds Production:
3,6-DIFLUORO-2-HYDROXYBENZOIC ACID serves as a precursor to produce other fluorinated organic compounds, which are valuable in various applications across different industries.

InChI:InChI=1/C7H4F2O3/c8-3-1-2-4(9)6(10)5(3)7(11)12/h1-2,10H,(H,11,12)

Upstream product

• 887267-03-0 3,6-difluoro-2-methoxybenzoic acid 
• 75626-17-4 2,5-difluoroanisole 
• 2713-31-7 2,5-difluorophenol 
• 124-38-9 carbon dioxide 
• 749230-16-8 1,4-difluoro-2-(methoxymethoxy)benzene 

Relevant articles and documents

Fluorine analogs of dicamba and tricamba herbicides; Synthesis and their pesticidal activity

Fluorine analogs of the dicamba and tricamba herbicides were synthesized. Their herbicide activities were compared with the activities of the pattern herbicides dicamba and tricamba.

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.