7500-54-1

Basic information

• Product Name: o-Benzenediacetamide
• CAS NO: 7500-54-1
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• Mol File: 7500-54-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: o-Benzenediacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: o-Benzenediacetamide(7500-54-1)
• EPA Substance Registry System: o-Benzenediacetamide(7500-54-1)

Safety Data

• Hazardous Substances Data: 7500-54-1(Hazardous Substances Data)

Upstream product

• 613-73-0 1,2-phenylenediacetonitrile 

Downstream Products

• 2184-00-1 2,4-Dioxo-2,3,4,5-tetrahydro-1H-3-benzazepin 
• 87813-67-0 (2-carbamoylmethyl-phenyl)-acetic acid 
• 7500-53-0 1,2-Phenylenediacetic acid 
• 15987-50-5 1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one 
• 15299-53-3 3-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benz[d]azepine 

Relevant articles and documents

Transfer Hydration of Dinitriles to Dicarboxamides

We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1, n -dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.

Rationalisation of the regioselective hydrolysis of aliphatic dinitriles with Rhodococcus rhodochrous AJ270

Aliphatic dinitriles undergo regioselective hydrolysis with the title organism to give monoacids with up to four methylenes between the nitrile functions (optimally 2-3) or when either an oxygen is placed β, γ or δ to the nitrile (δ-placement being optimal) or β or γ (optimally γ) but not δ sulfur substituents are present; nitrogen substituents appear to behave as for oxygen but suffer a steric limitation of the size of the nitrogen substituent.