75007-70-4

Basic information

• Product Name: Latamoxef Impurity 1
• Synonyms: Latamoxef Impurity 1
• CAS NO: 75007-70-4
• Molecular Formula: C₁₉H₂₀N₆O₇S
• Molecular Weight: 476.46
• Mol File: 75007-70-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Latamoxef Impurity 1(CAS DataBase Reference)
• NIST Chemistry Reference: Latamoxef Impurity 1(75007-70-4)
• EPA Substance Registry System: Latamoxef Impurity 1(75007-70-4)

Safety Data

• Hazardous Substances Data: 75007-70-4(Hazardous Substances Data)

Upstream product

• 86862-92-2 diphenylmethyl <4-<(benzyloxycarbonyl)oxy>phenyl>acetate 
• 86862-84-2 Carbonic acid benzyl ester 4-chlorocarbonylmethyl-phenyl ester 
• 86862-83-1 <4-<(benzyloxycarbonyl)oxy>phenyl>acetic acid 
• 78984-21-1 diphenylmethyl (4-hydroxyphenyl)acetate 
• 66510-99-4 (6R,7R)-benzhydryl-7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 156-38-7 4-hydroxyphenylacetate 
• 114652-98-1 2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)acetic acid 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 315663-45-7 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 64952-97-2 moxalactam 
• 86862-88-6 (6R,7R)-7-[2-(4-Benzyloxycarbonyloxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Downstream Products

• 206854-63-9 (6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester 
• 315663-51-5 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid 3-methyl-benzyl ester 
• 206854-38-8 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester 

Relevant articles and documents

Degradation and epimerization kinetics of moxalactam in aqueous solution

The kinetics of epimerization and degradation of moxalactam in aqueous solution was investigated by HPLC. The pH-rate profiles of the degradation and epimerization were determined separately over the pH range of 1.0-11.5 at 37°C and constant ionic strength 0.5. The degradation and simultaneous epimerization were followed by measuring both of the residual R- and S-epimers of moxalactam and were found to follow pseudo-first-order kinetics. The degradation was subjected to hydrogen ion and hydroxide ion catalyses and influenced by the dissociation of the side chain phenolic group. The epimerization rates were influenced significantly in the acidic region by the dissociation of the side chain carboxylic acid group and in the basic region by hydroxide ion catalysis. The pH-degradation rate profile of moxalactam showed a minimum degradation rate constant between pH 4.0 and 6.0. The pH-epimerization rate profiles of moxalactam showed minimum epimerization rate constants at pH 7.0. The epimerization rate constant of the R- and S-epimers were not very different.

Synthesis and Substituent Effects on Antibacterial Activity, Alkaline Hydrolysis Rates, and Infrared Absorption Frequencies of Some Cephem Analogues Related to Latamoxef (Moxalactam)

Relationships between intrinsic antibacterial activity and β-lactam reactivity of 7β-amino- and 7β-amino derivatives of 1-oxa- and 1-thiacephems, with or without the 7α-methoxy group (1-8), were investiga