7510-48-7

Basic information

• Product Name: N-(3-bromophenyl)-4-methylbenzenesulfonamide
• Synonyms: benzenesulfonamide, N-(3-bromophenyl)-4-methyl-
• CAS NO: 7510-48-7
• Molecular Formula: C₁₃H₁₂BrNO₂S
• Molecular Weight: 326.2089
• Mol File: 7510-48-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 429.7°C at 760 mmHg
• Flash Point: 213.7°C
• Density: 1.545g/cm³
• Vapor Pressure: 1.38E-07mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: N-(3-bromophenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-bromophenyl)-4-methylbenzenesulfonamide(7510-48-7)
• EPA Substance Registry System: N-(3-bromophenyl)-4-methylbenzenesulfonamide(7510-48-7)

Safety Data

• Hazardous Substances Data: 7510-48-7(Hazardous Substances Data)

Usage

General Description

N-(3-bromophenyl)-4-methylbenzenesulfonamide, also known as 3-Bromo-4-methylbenzenesulfonamide, is a chemical compound composed of a sulfonamide group, a 3-bromophenyl group, and a 4-methylbenzene group. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals, due to its ability to act as a sulfonamide-based antimicrobial agent. N-(3-bromophenyl)-4-methylbenzenesulfonamide can also be utilized in the production of dyes, pigments, and other organic compounds. It is important to handle this chemical with care, as it is known to irritate the skin and eyes, and may be harmful if ingested or inhaled.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 591-19-5 m-Bromoaniline 
• 95-14-7 1,2,3-Benzotriazole 
• 585-79-5 m-nitrobromobenzene 
• 1028-19-9 1-(4'-methylbenzenesulfonyl)-1H-benzo[d][1.2.3]triazole 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 66584-32-5 3-bromo-N-methylaniline 
• 252936-78-0 N-(3-bromo-phenyl)-4,N-dimethyl-benzenesulfonamide 
• 4964-71-0 5-bromoquinoline 
• 1380159-59-0 4-bromo-3-[(E)-phenylmethylidene]-1-tosylindoline 
• 1620787-24-7 N-(5-bromo-2-nitrophenyl)-4-methylbenzenesulfonamide 
• 1620787-25-8 N-(3-bromo-4-nitrophenyl)-4-methylbenzenesulfonamide 
• 925706-98-5 4-methyl-N-(3-octylphenyl) benzenesulfonamide 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Metal-free one-pot synthesis of N-arylsulfonamides from nitroarenes and sodium sulfinates in an aqueous medium

A metal-free one-pot two-step synthesis of sulfonamides from readily available nitroarenes and sodium arylsulfinates in a mixture of methanol and water has been developed. In this procedure, the aryl amines were produced in situ by the reduction of nitroarenes mediated by diboronic acid, and then coupled with sodium arylsulfinates in the presence of iodine. A series of N-arylsulfonamides with various functional groups were obtained in moderate to good yields under the optimal reaction conditions. In addition, this one-pot process is applicable for gram-scale synthesis.

Synthesis, Characterization, and Reactivity of an Ethynyl Benziodoxolone (EBX)-Acetonitrile Complex

The synthesis of a crystalline ethynyl-1,2-benziodoxol-3(1H)-one (EBX)-acetonitrile complex is described. EBX has been widely used as an active species for a variety of reactions; however, its high instability has so far prevented its isolation. The EBX-acetonitrile is self-assembled into a double-layered honeycomb structure through weak hypervalent iodine secondary interactions and hydrogen bonding. The N-ethynylation of a variety of sulfonamides using the EBX-acetonitrile complex as a substrate under mild conditions is also described.