751459-12-8Relevant articles and documents
Synthesis and structure-activity relationship of C-3 substituted triazolylthiomethyl cephems
Singh,Fiakpui,Galpin,Stewart,Singh,Micetich
, p. 301 - 309 (2007/10/03)
A series of C-3 substituted triazolylthiomethyl cephems with an aminothiazolemethoxyiminoacetamido side chain at C-7 were synthesized and tested for antimicrobial activity against clinically-relevant isolates. The compound with 3-pyridyl at C-5 and methyl at N-4 of the triazole moiety exhibited good antibacterial activity against both Gram-positive and Gram-negative bacteria, with the exception of pseudomonas spp against which none of the derivatives exhibited favorable activity.