75199-40-5Relevant articles and documents
Structural modification and antihypertensive activity study of formononetin derivatives
Guo, Qiu-Hong,Li, Jing,Ma, Dong-Lai,Zhou, Li,Zuo, Sai-Jie
, (2021/12/09)
A series of formononetin derivatives with substituted benzyloxy groups on the 4′ position of isoflavone were designed and synthesized. Their vasodilative activities were evaluated by wire myograph system on isolated rat mesenteric arterial ring. The preli
Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos
Tamura, Satoru,Yoshihira, Kunichika,Tokumaru, Mariko,Zisheng, Xu,Murakami, Nobutoshi
scheme or table, p. 3872 - 3875 (2010/08/19)
Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (FcRI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FcRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of γ-chain subunit to suppress expression of FcRI among the three subunits.
