752235-77-1

Basic information

• Product Name: 4-benzyloxybutyl chlorocarbonate
• Synonyms: 4-benzyloxybutyl chlorocarbonate
• CAS NO: 752235-77-1
• Molecular Weight: 242.702
• Mol File: 752235-77-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyloxybutyl chlorocarbonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyloxybutyl chlorocarbonate(752235-77-1)
• EPA Substance Registry System: 4-benzyloxybutyl chlorocarbonate(752235-77-1)

Safety Data

• Hazardous Substances Data: 752235-77-1(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 4541-14-4 4-benzyloxy-butan-1-ol 

Downstream Products

• 752235-78-2 tert-butyl N-(4-benzyloxybutoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate 
• 752235-80-6 tert-butyl 3-{[((5R)-3-{4-[(acetyloxyamino)(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-(4-benzyloxybutoxycarbonyl)-L-alaninate 
• 752235-79-3 tert-butyl N-(4-benzyloxybutoxycarbonyl)-3-{[((5R)-3-{4-[(hydroxyamino)(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-L-alaninate 
• 752235-81-7 3-{[((5R)-3-{4-[(acetyloxyamino)(imino)methyl]phenyl}-4,5-dihydro-5-isoxazolyl)acetyl]amino}-N-(4-benzyloxybutoxycarbonyl)-L-alanine 

Relevant articles and documents

Synthesis of N-butyl side chain hydroxylated metabolites of roxifiban, a platelet glycoprotein IIB/IIIA receptor antagonist

Syntheses of three n-butyl side chain hydroxylated metabolites of Roxifiban (5, 6a and 6b) are reported. Initial use of benzyl as hydroxyl protecting group gave poor yield during its removal by catalytic hydrogenation, due to complication from N-O cleavage of the isoxazoline. This problem was eliminated by the use of TBDMS as the hydroxyl protecting group. The chemical structures of these metabolites as well as the intermediates have been fully characterized.