75227-11-1

Basic information

• Product Name: Ethyl 5-(p-tolyl)hexanoate
• Synonyms: Ethyl 5-(p-tolyl)hexanoate
• CAS NO: 75227-11-1
• Molecular Weight: 234.338
• Mol File: 75227-11-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethyl 5-(p-tolyl)hexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-(p-tolyl)hexanoate(75227-11-1)
• EPA Substance Registry System: Ethyl 5-(p-tolyl)hexanoate(75227-11-1)

Safety Data

• Hazardous Substances Data: 75227-11-1(Hazardous Substances Data)

Upstream product

• 5838-08-4 1-(3-bromo-1-methyl-propyl)-4-methyl-benzene 
• 122-00-9 para-methylacetophenone 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 106-38-7 para-bromotoluene 
• 4761-26-6 ethyl 2-carbethoxy-5-oxocaproate 
• 13984-57-1 ethyl 5-oxohexanoate 
• 75227-09-7 2-(3-p-Tolyl-butyl)-malonic acid diethyl ester 
• 83912-17-8 Ethyl 5-hydroxy-5-(p-tolyl)hexanoate 
• 130362-05-9 ethyl (E)-5-hydroxy-5-(4-methylphenyl)hex-2-enoate 

Downstream Products

• 93741-96-9 2-Hydroxy-2-methyl-6-(p-tolyl)heptane 
• 644-30-4 ar-curcumene 
• 6089-98-1 10-(p-Tolyl)-2-methyl-6-methylen-undecen-⁽²⁾ 
• 28591-18-6 5-(4-methylphenyl)hexan-1-ol 
• 78518-93-1 5-(p-Tolyl)-hexanal 
• 70329-63-4 (+/-)-5,6-dehydrosenedigitalene 
• 26127-21-9 2-Methyl-6-oxo-10-p-tolyl-undeca-2-en 

Relevant articles and documents

Synthesis of bisabolane sesquiterpenes: A Johnson-Claisen rearrangement approach

Several bisabolane sesquiterpenes, (±)-curcumene, (±)-curcuphenol, (±)-curcudiol and (±)-curcuhydroquinone, have been synthesized in racemic form and fully characterized. The salient characteristic of our approach is that a Johnson-Claisen arrangement was

A New Synthesis of (+/-)-5,6-Dehydrosenedigitalene

Ethyl 2-carbethoxy-5-oxohexanoate (II) on heating with NaCl in DMSO-water mixture gives the monoester (III) which when submitted to selective Grignard reaction with p-tolylmagnesium bromide furnishes ethyl 5-hydroxy-5-(p-tolyl)hexanoate (IV).The benzylic alcohol (IV) on catalytic hydrogenolysis gives ethyl 5-(p-tolyl)hexanoate (V) which on reduction with LAH provides the alcohol (VI).Oxidation of VI with Corey's reagent furnishes the aldehyde (VII) which on Wittig reaction with methylenetriphenylphosphorane in DMSO yields the title compound (I).