75238-09-4

Basic information

• Product Name: N-(6-Aminohexyl)maleimide hydrochloride salt
• Synonyms: N-(6-Aminohexyl)maleimide hydrochloride salt;N-(6-Aminohexyl)maleimide hydrochloride;N-(6-AMinohexyl)MaledeiMide hydrochloride salt;1-(6-aminohexyl)pyrrole-2,5-dione;1-(6-AMINOHEXYL)-1H-PYRROLE-2,5-DIONE HCL
• CAS NO: 75238-09-4
• Molecular Formula: C10H16N2O2.ClH
• Molecular Weight: 232.709
• Mol File: 75238-09-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 365.7 °C at 760 mmHg
• Flash Point: 175 °C
• Appearance: /
• CAS DataBase Reference: N-(6-Aminohexyl)maleimide hydrochloride salt(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-Aminohexyl)maleimide hydrochloride salt(75238-09-4)
• EPA Substance Registry System: N-(6-Aminohexyl)maleimide hydrochloride salt(75238-09-4)

Safety Data

• Hazardous Substances Data: 75238-09-4(Hazardous Substances Data)

Usage

General Description

N-(6-Aminohexyl)maleimide hydrochloride salt is a chemical compound used in biochemical research and biotechnology. It is a maleimide derivative that contains a six-carbon linker with an amino group at one end. N-(6-Aminohexyl)maleimide hydrochloride salt is commonly used as a crosslinking reagent in protein chemistry and can react with thiol-containing compounds to form stable covalent bonds. It is often used in the modification and labeling of proteins, peptides, and other biomolecules for various analytical and research purposes. N-(6-Aminohexyl)maleimide hydrochloride salt is a valuable tool in the study of protein structure, function, and interactions within biological systems.

Upstream product

• 4048-33-3 6-amino-1-hexanol 
• 124529-64-2 tert-butyl (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl)carbamate 
• 207558-25-6 hexylcarbamic acid tert-butyl ester 

Relevant articles and documents

Efficient Synthesis of a Family of Bifunctional Chelators Based on the PCTA[12] Macrocycle Suitable for Bioconjugation

PCTA[12] is a 12-membered tetraaza-macrocyclic ligand that incorporates a pyridine unit within the macrocyclic ring and three acetate pendant arms. Unlike DOTA and NOTA chelators, PCTA is a recent entry to the field of macrocyclic polyaminocarboxylate ligands available to complex a variety of M2+/M3+ ions for biomedical applications such as diagnostic and radiotherapeutic. Despite the promising properties of its chelates, only a few of bifunctional chelating agents (BFCAs) derived from PCTA have been described so far. Based on our very recent methodology for the preparation of PCTA[12] itself, we report here the efficient synthesis of several BFCAs derived from PCTA bearing a free reactive function group, mainly devoted to conjugation purposes: ester, carboxylic acid, alcohol, aliphatic amine, aromatic amine, maleimide, bromo or azide functions. These functions were introduced either on the 4-position of the pyridine ring or on the methylene carbon atom of the central acetate chelating arm, while keeping the three carboxylate groups available for metal chelation. Moreover, two of these BFCAs-PCTA were used for conjugation with a tetrapeptide (cholecystokinin analogue), a bioactive molecule (biotin), or a solid support (silica gel).