75238-44-7 Usage
Description
5-Benzyloxyindole-3-glyoxylic Acid Ethyl Ester is an organic compound that serves as a crucial intermediate in the synthesis of various biologically active molecules. It is characterized by its unique chemical structure, which includes a benzyloxyindole core and a glyoxylic acid ethyl ester functional group. 5-BENZYLOXYINDOLE-3-GLYOXYLIC ACID ETHYL ESTER plays a significant role in the development of pharmaceuticals and other related applications due to its ability to be further modified and incorporated into more complex molecules.
Uses
Used in Pharmaceutical Synthesis:
5-Benzyloxyindole-3-glyoxylic Acid Ethyl Ester is used as an intermediate in the synthesis of 5-Hydroxy Tryptophol-d4 β-D-Glucuronide (H976012), a labelled metabolite of 5-Hydroxytryptamine (H974990). This application is particularly relevant in the field of pharmaceuticals, as it aids in the development of new drugs and therapies targeting various medical conditions.
Used in Chemical Research:
In addition to its pharmaceutical applications, 5-Benzyloxyindole-3-glyoxylic Acid Ethyl Ester is also utilized in chemical research for the exploration of new synthetic pathways and the development of novel compounds with potential applications in various industries. Its unique structure and reactivity make it a valuable tool for researchers in the field of organic chemistry.
Used in Drug Delivery Systems:
Similar to gallotannin, 5-Benzyloxyindole-3-glyoxylic Acid Ethyl Ester can be employed in the development of drug delivery systems to enhance the bioavailability and therapeutic outcomes of various pharmaceuticals. By incorporating this compound into the design of drug carriers, researchers can potentially improve the delivery and efficacy of drugs targeting specific medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 75238-44-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,2,3 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75238-44:
(7*7)+(6*5)+(5*2)+(4*3)+(3*8)+(2*4)+(1*4)=137
137 % 10 = 7
So 75238-44-7 is a valid CAS Registry Number.
InChI:InChI=1/C19H17NO4/c1-2-23-19(22)18(21)16-11-20-17-9-8-14(10-15(16)17)24-12-13-6-4-3-5-7-13/h3-11,20H,2,12H2,1H3
75238-44-7Relevant articles and documents
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. Possible new GSK-3β therapies for bipolar disorders
Kozikowski, Alan P.,Gaisina, Irina N.,Yuan, Hongbin,Petukhov, Pavel A.,Blond, Sylvie Y.,Fedolak, Allison,Caldarone, Barbara,McGonigle, Paul
, p. 8328 - 8332 (2008/02/09)
More than two million American adults, or approximately one percent of the population 18 years or older, suffer from bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid. Both are relatively dated drugs that are only partially effective and produce various undesirable side effects including weight gain. Based upon continued efforts to understand the molecular target for lithium, it now appears that specific inhibitors of the enzyme glycogen synthase kinase-3β (GSK-3β) may mimic the therapeutic action of mood stabilizers and might therefore allow for the design of improved drugs for treating patients with bipolar disorder as well as certain neurodegenerative disorders. Furthermore, the pro-apoptotic properties of the GSK-3 enzyme suggest the possible use of such inhibitors as neuroprotective agents. In fact, neuroprotection may contribute to the treatment of mood disorders. The present chemistry, modeling, and biology efforts have identified 3-benzofuranyl-4-indolylmaleimides as potent and relatively selective GSK-3β inhibitors. The best ligand in this series (having a Ki value of 4.6 nM against GSK-3β) was studied in a novel mouse model of mania that has recently been validated with several clinically effective mood stabilizers. This study presents the first demonstration of the efficacy of a GSK-3β inhibitor in this mouse model of mania. Selective brain penetrable GSK-3 ligands like those described herein become valuable research tools in better defining the role of this multifaceted kinase in both physiological and pathophysiological events.
