75251-24-0

Basic information

• Product Name: 4-ETHYLPHENYLACETONE
• Synonyms: 4-ETHYLPHENYLACETONE;4-Ethylphenylacetone,98%;4-Ethylphenylacetone, 97+%;1-(4-Ethylphenyl)propan-2-one
• CAS NO: 75251-24-0
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.23
• Product Categories: Aromatic Ketones (substituted)
• Mol File: 75251-24-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 241.0±9.0℃ (760 Torr)
• Flash Point: 101.3±7.3℃
• Appearance: Yellow powder
• Density: 0.961±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0368mmHg at 25°C
• Refractive Index: 1.5120
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-ETHYLPHENYLACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYLPHENYLACETONE(75251-24-0)
• EPA Substance Registry System: 4-ETHYLPHENYLACETONE(75251-24-0)

Safety Data

• Hazardous Substances Data: 75251-24-0(Hazardous Substances Data)

Usage

General Description

4-Ethylphenylacetone is a chemical compound primarily used in the pharmaceutical industry for the synthesis of drugs and other intermediate pharmaceutical aids. It is not widely found in nature but is instead synthesized in laboratories. 4-ETHYLPHENYLACETONE, often referred to as a ‘precursor’ substance, can be used in the illegal production of amphetamine. Hence, its distribution and usage are closely monitored in many jurisdictions. As with any chemical substance, handling of 4-Ethylphenylacetone should be done with care to avoid skin and eye irritation or inhalation. Its environmental impact has not been extensively studied.

InChI:InChI=1/C11H14O/c1-3-10-4-6-11(7-5-10)8-9(2)12/h4-7H,3,8H2,1-2H3

Upstream product

• 7487-94-7 mercury (II) chloride 
• 7429-90-5 aluminium 
• 108-22-5 Isopropenyl acetate 
• 589-16-2 4-aminoethylbenzene 
• 52436-73-4 4-ethylbenzenediazonium tetrafluoroborate 
• 1401722-49-3 C₁₁H₁₂N₂O₃S 
• 67-64-1 acetone 
• 1139705-25-1 4-methoxyphenyl 1H-imidazole-1-sulfonate 
• 91121-32-3 2-acetyl-(4-ethylphenyl)acetonitrile 

Downstream Products

• 65768-19-6 3-(4-ethylphenyl)butan-2-one 
• 13031-43-1 4-acetyloxyacetophenone 
• 620-85-9 1-benzyl-4-ethylbenzene 
• 75250-79-2 (E)-N-<2-(4-Ethylphenyl)-1-methylethyliden>benzolamin 
• 75250-78-1 (Z)-N-<2-(4-Ethylphenyl)-1-methylethyliden>benzolamin 

Relevant articles and documents

Iron powder and tin/tin chloride as new reducing agents of Meerwein arylation reaction with unexpected recycling to anilines

Simple and rapid route for Meerwein arylation reaction using iron powder or a mixture of tin/tin chloride has been developed. In the presence of iron powder, different aryl diazonium salts reacted with methyl vinyl ketone, acrylates, and isopropenyl acetate. Production of oximes was detected as the main product with acrylates or in a mixture with β-aryl methyl ketones in the case of methyl vinyl ketone. The in situ produced HNO2 from an excess of NaNO2/HCl was trapped by alkyl aryl radical to form oximes in the E configuration form. The presence of tin/tin chloride mixture in the reaction of the aryl diazonium salts with methyl vinyl ketone produced Michael products along with β-aryl methyl ketones. The predicted α-aryl methyl ketones from the reaction of isopropenyl acetate with the diazotized anilines were obtained using iron or tin/tin chloride mixture.

Palladium-catalyzed mono-α-arylation of acetone with aryl imidazolylsulfonates

Set the ace(tone): A palladium catalyst derived from the bidentate XantPhos ligand and Pd(OAc)2 has enabled broadly applicable mono-α-arylations of acetone to be performed with air- and moisture-stable aryl imidazolylsulfonates as most user-friendly electrophiles (see scheme). Copyright

Quantitative relations between structure and activation of fibrinolysis in selected series of arylaliphatic acids

-