75258-86-5

Basic information

• Product Name: 2-p-Hydroxybenzylidene-5-methoxy-1-indanone
• CAS NO: 75258-86-5
• Molecular Weight: 266.296
• Mol File: 75258-86-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-p-Hydroxybenzylidene-5-methoxy-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-p-Hydroxybenzylidene-5-methoxy-1-indanone(75258-86-5)
• EPA Substance Registry System: 2-p-Hydroxybenzylidene-5-methoxy-1-indanone(75258-86-5)

Safety Data

• Hazardous Substances Data: 75258-86-5(Hazardous Substances Data)

Upstream product

• 5111-69-3 5-methoxyindane 
• 5111-70-6 5-methoxy-1-indanone 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 75258-87-6 2-p-Acetoxybenzylidene-5-methoxy-1-indanone 

Relevant articles and documents

Studies in Antifertility Agents: Part XXV - 2-Carboxy-7-hydroxy-1-phenyl-1,2,3,4-tetrahydrofluorene

The synthesis and stereochemical assignments of 2-carboxy-7-hydroxy-1-phenyl-1,2,3,4-tetrahydrofluorene (17) are reported. 2-Arylidene-5-methoxy-1-indanones (5-8) have been prepared by condensation of 5-methoxy-1-indanone (1) with araldehydes (2-4).Addition of methyl acetoacetate onto 5 furnishes 2-carbomethoxy-7-methoxy-3-oxo-1-phenyl-1,2,3,9a-tetrahydrofluorene (9), which under acid hydrolysis gives the enone (10), and on treatment with ethanedithiol affords the thioketal (11).Desulphurization of 11 with Raney nickel yields 1,2-trans-2-carbomethoxy-7-methoxy-1-phenyl-1,2,3,4-tetrahydrofluorene (12).Catalytic hydrogenation of 12 affords possibly B/C-cis-1,2-trans-1,2,3,4,4a,9a-hexahydrofluorene (13).Alkaline hydrolysis of esters 11, 12 and 13 gives the corresponding acids 15, 16 and 14.Demethylation of 16 with BBr3-CH2Cl2 furnishes the title hydroxy acid (17).None of these compounds prevents pregnancy at a dose of 10 mg/kg in rats.