75262-69-0

Basic information

• Product Name: 17β-Carboxy-17-desoxy Dexamethasone
• Synonyms: (11β,16α,17β)-9-Fluoro-11-hydroxy-16-Methyl-3-oxoandrosta-1,4-diene-17-carboxylic Acid;17β-Carboxy 17-DesoxyMethasone;17-Beta-Carboxy-17-Desoxy-DexaMethasone;DexaMethasone Acid IMpurity;Desoximetasone Oxidative Impurity;17β-Carboxy-17-desoxy Dexamethasone;172-Carboxy-17-desoxy Dexamethasone
• CAS NO: 75262-69-0
• Molecular Formula: C21H27FO4
• Molecular Weight: 362.4350832
• Product Categories: Pharmaceuticals;Steroids;Impurities;Intermediates & Fine Chemicals
• Mol File: 75262-69-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 294-296°C (dec.)
• Boiling Point: 529.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• PKA: 4.50±0.70(Predicted)
• CAS DataBase Reference: 17β-Carboxy-17-desoxy Dexamethasone(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-Carboxy-17-desoxy Dexamethasone(75262-69-0)
• EPA Substance Registry System: 17β-Carboxy-17-desoxy Dexamethasone(75262-69-0)

Safety Data

• Hazardous Substances Data: 75262-69-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

An impurity of Dexamethasone (D298800), Desoxymethasone,

Upstream product

• 382-67-2 desoximetasone 

Relevant articles and documents

9α-fluoro-16α-methyl-3,11-dioxoan-drosta-1,4-diene-17β- carboxylic acid: Catemeric hydrogen bonding and acetic acid solvation in a steroidal keto acid related to dexamethasone

The title keto acid crystallizes as a solvate, C21H25-FO4·C2H4 O2, with two molecules each of steroid and acetic acid per asymmetric unit. The former are approximately parallel, with opposite end-to-end orientation, and form translational carboxyl-to-ketone hydrogen-bonding catemers [O...;O = 2.679 (6) and 2.650 (5) A, and O-H...O = 165 and 162] that involve the 3-ketone group and follow the a axis. The acetic acid molecules are paired by hydrogen bonding, and neither they nor the F atom nor the 11-ketone group play any overt role in the hydrogen-bonding scheme of the steroid. Intermolecular C-H...O=C close contacts involving three different neighboring molecules exist to the 11-ketone group, the steroidal carboxyl group and one of the acetic acid molecules.