753005-92-4

Basic information

• Product Name: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-[3-(4-ethylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
• Synonyms: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-[3-(4-ethylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
• CAS NO: 753005-92-4
• Molecular Weight: 0
• Mol File: 753005-92-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-[3-(4-ethylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-[3-(4-ethylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile(753005-92-4)
• EPA Substance Registry System: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-[3-(4-ethylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile(753005-92-4)

Safety Data

• Hazardous Substances Data: 753005-92-4(Hazardous Substances Data)

Upstream product

• 622369-82-8 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-ethoxy-3-quinolinecarbonitrile 
• 622369-81-7 3-(4-ethylpiperazin-1-yl)propan-1-ol 

Relevant articles and documents

TREATMENT OF IMATINIB RESISTANT LEUKEMIA

The present invention provides 4-anilino-3-quinolinecarbonitriles compounds useful for treating a subject having an BcrAbl positive leukemia that is resistant to imatinib.

4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML)

Compounds of the formula: wherein: n is an integer from 1-3; X is N, CH, provided that when X is N, n is 2 or 3; R is alkyl of 1 to 3 carbon atoms; R1 is 2,4-diCl, 5-OMe; 2,4-diCl; 3,4,5-tri-OMe; 2-Cl, 5-OMe; 2-Me, 5-OMe; 2,4-di-Me; 2,4-diMe-5-OMe, 2,4-diCl, 5-OEt; R2 is alkyl of 1 to 2 carbon atoms, and pharmaceutically acceptable salts thereof.