753029-08-2Relevant articles and documents
Tetrahydroisoquinolines as MCH-R1 antagonists
Sasikumar,Qiang,Wu,Burnett,Greenlee,O'Neill,Hawes,van Heek,Graziano
, p. 4917 - 4921 (2008/09/21)
A series of potent and selective inhibitors of h-MCH-R1 has been developed based on the piperidine glycineamide compounds I and II. These structurally more rigid tetrahydroisoquinolines (III and IV) showed better pharmacokinetics. The highly potent compounds 12d and 12g displayed excellent rat pk.
