753455-73-1

Basic information

• Product Name: 3,8-diamino-1-(4-methoxyphenyl)-1H-benzo[h]chromene-2-carbonitrile
• Synonyms: 3,8-diamino-1-(4-methoxyphenyl)-1H-benzo[h]chromene-2-carbonitrile
• CAS NO: 753455-73-1
• Molecular Weight: 343.385
• Mol File: 753455-73-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,8-diamino-1-(4-methoxyphenyl)-1H-benzo[h]chromene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,8-diamino-1-(4-methoxyphenyl)-1H-benzo[h]chromene-2-carbonitrile(753455-73-1)
• EPA Substance Registry System: 3,8-diamino-1-(4-methoxyphenyl)-1H-benzo[h]chromene-2-carbonitrile(753455-73-1)

Safety Data

• Hazardous Substances Data: 753455-73-1(Hazardous Substances Data)

Upstream product

• 83-55-6 5-amino-1-naphthol 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

Structure-activity relationships and molecular docking studies of chromene and chromene based azo chromophores: A novel series of potent antimicrobial and anticancer agents

The design of novel materials with significant biological properties is a main target in drug design research. Chromene compounds represent an interesting medicinal scaffold in drug replacement systems. This report illustrates a successful synthesis and characterization of two novel series of chromene compounds using multi-component reactions. The synthesis of the first example of azo chromophores containing chromene moieties has also been established using the same methodology. The antimicrobial activity of the new molecules has been tested against seven human pathogens including two Gm+ve, two Gm-ve bacteria, and four fungi, and the results of the inhibition zones with minimum inhibitory concentrations were reported as compared to reference drugs. All the designed compounds showed significant potent antimicrobial activities, among of them, four potent compounds 4b, 4c, 13e, and 13i showed promising MIC from 0.007 to 3.9 μg/mL. In addition, antiproliferative analysis against three target cell lines was examined for the novel compounds. Compounds 4a, 4b, 4c, and 7c possessed significant antiproliferative activity against three cell lines with an IC50 of 0.3 to 2 μg/mL. Apoptotic analysis was performed for the most potent compounds via caspase enzyme activity assays as a potential mechanism for their antiproliferative effects. Finally, the computational 2D QSAR and docking simulations were accomplished for structure-activity relationship analyses.

Synthesis of hydroxyquinoline derivatives, amino-hydroxychromene, aminocoumarin and their anti-bacterial activities

Some new diaminochromenes (3a-f, 7a-c, and 10), 7-amino-4-aryl-coumarins (8a,b), 7-hydroxy-4-aryl-1,2-dihydroquinolines (9a-c) and 2-amino-7-hydroxy-4- (4-chlorophenyl)-4H-chromenes (16a-d) were synthesized via Michael addition of different substituted am