75347-16-9

Basic information

• Product Name: 3H-Purin-6-amine, 3-[(4-nitrophenyl)methyl]-
• CAS NO: 75347-16-9
• Molecular Formula: C12H10N6O2
• Molecular Weight: 270.25
• Mol File: 75347-16-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3H-Purin-6-amine, 3-[(4-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Purin-6-amine, 3-[(4-nitrophenyl)methyl]-(75347-16-9)
• EPA Substance Registry System: 3H-Purin-6-amine, 3-[(4-nitrophenyl)methyl]-(75347-16-9)

Safety Data

• Hazardous Substances Data: 75347-16-9(Hazardous Substances Data)

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 73-24-5 7H-purin-6-ylamine 
• 66224-66-6 adenine 

Downstream Products

• 3691-50-7 7-benzyladenine 
• 115929-19-6 7-(3,5-Dimethoxy-benzyl)-7H-purin-6-ylamine 
• 115929-18-5 7-(3-Methoxybenzyl)adenine 

Relevant articles and documents

Heterocyclic Ambident Nucleophiles. III* The Alkylation of Sodium Adenide

The alkylation of sodium adenide in HCONMe2 (30 deg) with various alkylating agents was analysed by 1H n.m.r. spectroscopy.Widely varying N3:N7:N9 alkylation patterns were observed, depending on the alkylating agent.These patterns are interpreted in terms of the electrostatic, thermodynamic and steric factors involved in the different SN2 transition states appropriate to each alkylating agent.Hydrogen bonding association between the 6-amino group and certain carbonyl containing alkylating agents is proposed to explain the enhancedN7-alkylation in some cases.Support for this latter proposal was obtain from a comparison of the adenine alkylation results with the corresponding alkylation patterns of 6-pivaloylamino- and 6-chloro-purine.

Phase-Transfer Catalysis in the N-Benzylation of Adenine

A convenient phase-transfer catalysis in the N-benzylation of adenine is described.The benzylation of adenine with benzyl halides in a two-phase system containing phase-transfer catalyst gave 9-benzylated adenines as a major product accompanied with 3-benzylated adenines.