75347-53-4

Basic information

• Product Name: 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone
• Synonyms: 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone
• CAS NO: 75347-53-4
• Molecular Weight: 273.116
• Mol File: 75347-53-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone(75347-53-4)
• EPA Substance Registry System: 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone(75347-53-4)

Safety Data

• Hazardous Substances Data: 75347-53-4(Hazardous Substances Data)

Upstream product

• 62992-46-5 1-(tetrahydropyranyloxy)-4-pentyn 
• 7210-71-1 2,5-dichloro-3,6-dimethoxy-1,4-benzoquinone 
• 917-54-4 methyllithium 

Downstream Products

• 75347-58-9 5-acido-2-chloro-3-(5-hydroxy-1-pentenyl)-6-methyl-1,4-benzoquinone 
• 75347-60-3 2-acido-5-chloro-3-(5-hydroxy-1-pentenyl)-6-methyl-1,4-benzoquinone 
• 75347-59-0 2,5-dichloro-3-(5-hydroxy-1-pentenyl)-6-methyl-1,4-benzoquinone 
• 75365-46-7 2,5-dichloro-3-(5-hydroxy-1-pentenyl)-6-methylhydroquinone 

Relevant articles and documents

Synthesis of Substituted Quinones. 2,5-Disubstituted 1,4-Benzoquinones

Synthetic methodology is presented which allows the facile synthesis of 2,5-disubstituted 1,4-benzoquinones.This involves the initial 1,2-addition of an alkynyllithium reagent to one of the carbonyl groups of 2,5-diethoxy- or 2,5-dichloro-3,6-dimethoxy-1,4-benzoquinone.This is followed by an analogous addition of an alkyl-, aryl-, or alkynyllithium to the remaining carbonyl to give a cyclohexa-2,5-diene-1,4-diol derivative.Acid hydrolysis of these adducts results in the 2,5-dialkylated 1,4-benzoquinones.This methodology was employed to prepare 7-chloro-6-methyl-1,2,5,8-tetrahydro-3H-pyrroloindole-5,8-dione (14), a compound having the basic ring systeme of the mitomycin antineoplastic antibiotics.