753478-40-9

Basic information

• Product Name: 1-benzyl-2-methoxycarbonylamino-3-cyanopyrrole
• Synonyms: 1-benzyl-2-methoxycarbonylamino-3-cyanopyrrole
• CAS NO: 753478-40-9
• Molecular Weight: 255.276
• Mol File: 753478-40-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-2-methoxycarbonylamino-3-cyanopyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2-methoxycarbonylamino-3-cyanopyrrole(753478-40-9)
• EPA Substance Registry System: 1-benzyl-2-methoxycarbonylamino-3-cyanopyrrole(753478-40-9)

Safety Data

• Hazardous Substances Data: 753478-40-9(Hazardous Substances Data)

Upstream product

• 105788-28-1 1-benzyl-3-cyano-1H-pyrrole-2-carboxylic acid 
• 67-56-1 methanol 
• 753478-38-5 1-benzyl-3-cyano-1H-pyrrole-2-carbonyl azide 

Downstream Products

• 14052-84-7 7-benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 753478-33-0 2-amino-1-benzyl-3-cyanopyrrole 

Relevant articles and documents

Facile synthesis of 1-substituted 2-amino-3-cyanopyrroles: New synthetic precursors for 5,6-unsubstituted pyrrolo[2,3-d]pyrimidines

(Equation Presented) 1-Benzyl-3-cyanopyrrole-2-carbonyl azide (5) underwent a Curtius rearrangement followed by quenching with alcohols to form the corresponding carbamates (6a-c). The carbamates 6a,b were unblocked to give the desired 2-amino-1-benzyl-3-cyanopyrrole (1a). A more facile procedure was subsequently developed for the synthesis of 1-substituted 2-amino-3- cyanopyrroles. N-Substituted aminoacetaldehyde dimethyl acetals (7a-c) were condensed with malononitrile in the presence of p-toluenesulfonic acid monohydrate to afford the corresponding 1-substituted 2-amino-3-cyanopyrroles (1a-c).