75351-33-6Relevant articles and documents
Amphiphilic dendrimer, synthesis method thereof, and application of amphiphilic dendrimer as drug delivery system
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Paragraph 0096-0101; 0171-0172; 174-0176, (2021/08/07)
The invention relates to a microenvironment response type amphiphilic dendrimer, a synthesis method thereof, and application of the microenvironment response type amphiphilic dendrimer as a drug delivery system. The microenvironment response type amphiphilic dendrimer is a compound with a structure as shown in a formula (I), a formula (II) or a formula (III) or pharmaceutically acceptable salt of the compound. The compound disclosed by the invention can be used as the nano delivery system based on tumor microenvironment specific response, has good solubility in an aqueous solution, can be self-assembled with a drug in the aqueous solution to form a relatively stable nano compound, can effectively deliver the loaded drug to a tumor site; and can responsively disassembl the nano-drug delivery carrier under corresponding stimulation to achieve the purpose of accurate drug release, so that the drug can be released to the focus part to the greatest extent, and the compound is a novel nano-delivery carrier.
A metal-free reductive N-alkylation of indoles with aldehydes
Clanton, Nicholas A.,Spiller, Taylor E.,Ortiz, Eliezer,Gao, Zhinong,Rodriguez-Poirier, Juan Manuel,Delmonte, Albert J.,Frantz, Doug E.
supporting information, p. 3233 - 3236 (2021/04/05)
A simple metal-free method has been developed for the reductive N-alkylation of indoles employing aldehydes as the alkylating agent and inexpensive Et3SiH as the reductant. A wide range of aromatic and aliphatic aldehydes are viable substrates along with
Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds
Massaro, Nicholas P.,Pierce, Joshua G.
supporting information, p. 5079 - 5084 (2020/07/04)
The Amaryllidaceae alkaloids have been a target of synthesis for decades due to their complex architectures and biological activity. A central feature of these natural product cores is a quaternary substituted hydroindole heterocycle. Building off the fou