7537-07-7

Basic information

• Product Name: (2-chloro-3,4-dimethoxyphenyl)acetonitrile
• Synonyms: (2-chloro-3,4-dimethoxyphenyl)acetonitrile;2-Chloro-3,4-dimethoxybenzeneacetonitrile;Einecs 231-407-3
• CAS NO: 7537-07-7
• Molecular Formula: C₁₀H₁₀ClNO₂
• Molecular Weight: 211.6449
• EINECS: 231-407-3
• Mol File: 7537-07-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 324.9°C at 760 mmHg
• Flash Point: 150.3°C
• Appearance: /
• Density: 1.205g/cm³
• Vapor Pressure: 0.000238mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: (2-chloro-3,4-dimethoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-3,4-dimethoxyphenyl)acetonitrile(7537-07-7)
• EPA Substance Registry System: (2-chloro-3,4-dimethoxyphenyl)acetonitrile(7537-07-7)

Safety Data

• Hazardous Substances Data: 7537-07-7(Hazardous Substances Data)

Usage

General Description

(2-chloro-3,4-dimethoxyphenyl)acetonitrile is a chemical compound with the molecular formula C10H10ClNO2. It is a colorless to pale yellow liquid with a faint odor. (2-chloro-3,4-dimethoxyphenyl)acetonitrile is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes, pigments, and other organic compounds. (2-chloro-3,4-dimethoxyphenyl)acetonitrile is considered to be a hazardous material and should be handled with care, as it can cause skin and eye irritation upon contact. It is important to follow proper safety precautions and handling procedures when working with this chemical.

InChI:InChI=1/C10H10ClNO2/c1-13-8-4-3-7(5-6-12)9(11)10(8)14-2/h3-4H,5H2,1-2H3

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 621-59-0 isovanillin 
• 93983-14-3 2-chloro-3,4-dimethoxybenzyl chloride 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 7537-15-7 1-(2-Chloro-3,4-dimethoxy-phenyl)-propan-2-one 
• 102851-73-0 N-propyl-2-chlorodopamine 
• 102851-72-9 N-ethyl-2-chlorodopamine 
• 102851-71-8 N-methyl-2-chlorodopamine 
• 102851-70-7 2-chlorodopamine 
• 99318-58-8 N-(2-chlorohomoveratryl)propanamide 
• 102851-64-9 2-chlorohomoveratrylacetamide 
• 102851-63-8 (2-chlorohomoveratryl)formamide 
• 99318-59-9 N-(n-propyl)-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 102851-66-1 N-ethyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 102851-65-0 N-methyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 67227-56-9 fenoldopam 
• 71636-61-8 (+-)-6-chloro-7, 8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 104113-95-3 6-Chloro-1-(4-hydroxy-phenyl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide 

Relevant articles and documents

Heterocyclic compounds

The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Synthesis and Renal Vasodilator Activity of 2-Chlorodopamine and N-Substituted Derivatives

A four-step synthesis of 2-chlorodopamine (2b) is presented as well as methods for the syntheses of the N-methyl, ethyl, and n-propyl analogues (2c-e).Compounds 2b and 2c were essentially equipotent to dopamine for increasing renal blood flow in anesthesized dogs that had been treated with the α-adrenergic antagonist phenoxybenzamine.The increases in renal blood flow were blocked by the DA1 antagonist (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine.Compounds 2d and 2e were significantly less potent than dopamine in the same model; the increases in renal blood flow were attenuated by propanolol and blocked by a combination of propanolol and (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine.The significance of an o-chloro substituent on dopamine analogues for the activation of the DA1 receptor is briefly discussed.