75414-02-7

Basic information

• Product Name: 8-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE
• Synonyms: 8-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE
• CAS NO: 75414-02-7
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.18
• Mol File: 75414-02-7.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE(75414-02-7)
• EPA Substance Registry System: 8-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE(75414-02-7)

Safety Data

• Hazardous Substances Data: 75414-02-7(Hazardous Substances Data)

Usage

Derivative of tetrahydroquinoline

8-Fluoro-1,2,3,4-tetrahydroquinoline is a fluorinated derivative of tetrahydroquinoline, a bicyclic nitrogen-containing compound.

Building block

Commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity.

Fluorine atom

The fluorine atom in the compound provides unique properties for the development of new drugs and agricultural products.

Applications

Has potential applications in the field of organic chemistry and chemical research.

Structure

Interesting and important compound for various scientific and industrial purposes.

Upstream product

• 394-68-3 8-fluoroquinoline 
• 38470-28-9 8-fluoro-2,3-dihydro-1H-quinolin-4-one 

Downstream Products

• 394-68-3 8-fluoroquinoline 

Relevant articles and documents

Heterogeneous Hydrogenation of Quinoline Derivatives Effected by a Granular Cobalt Catalyst

We communicate a convenient method for the pressure hydrogenation of quinolines in aqueous solution by using a particulate cobalt-based catalyst that is prepared in situ from simple Co(OAc)2 4H2O through reduction with abundant zinc powder. This catalytic protocol permits a brisk and atom-efficient access to a variety of 1,2,3,4-tetrahydroquinolines thereby relying solely on easy-to-handle reagents that are all readily obtained from commercial sources. Both the reaction setup assembly and the autoclave charging procedure are conducted on the bench outside an inert-gas-operated containment system, thus rendering the overall synthesis time-saving and operationally very simple.

Homogeneous pressure hydrogenation of quinolines effected by a bench-stable tungsten-based pre-catalyst

We report on an operationally simple catalytic method for the tungsten-catalyzed hydrogenation of quinolines through the use of the easily handled and self-contained precursor [WCl(η5-Cp)(CO)3]. This half sandwich complex is indefinitely storable on the bench in simple screw-capped bottles or stoppered flasks and can, if required, be prepared on a multi-gram scale while the actual catalytic transformations were performed in the presence of a Lewis acid in order to achieve both decent substrate conversions and product yields. The described method represents a facile and atom-efficient access to a variety of 1,2,3,4-tetrahydroquinolines that circumvents the use of cost-intensive and oxygen-sensitive phosphine ligands as well as auxiliary hydride reagents.

Cu-Catalyzed Chemoselective Reduction of N-Heteroaromatics with NH3·BH3 in Aqueous Solution

An efficient catalytic system was successfully developed on reduction of N-heteroaromatics with H3N?BH3 as hydrogen source in CuSO4 solution, featuring excellent chemoselectivity as well as very broad functional group tolerance. Various challenging substrates, such as OH-, NH2-, Cl-, Br-, etc., contained quinolines, quinoxalines, 1,5-naphthyridines and quinazolines were all reduced smoothly. Mechanistic studies suggested that [Cu-H] intermediate might be generated from NH3?BH3, which was believed to form with H3N?BH3 in CuSO4 solution.