75416-52-3

Basic information

• Product Name: 6,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE
• Synonyms: 6,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE
• CAS NO: 75416-52-3
• Molecular Formula: C₉H₉Cl₂N
• Molecular Weight: 202.08046
• Mol File: 75416-52-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 302.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.293±0.06 g/cm3(Predicted)
• PKA: 8.28±0.20(Predicted)
• CAS DataBase Reference: 6,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE(75416-52-3)
• EPA Substance Registry System: 6,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE(75416-52-3)

Safety Data

• Hazardous Substances Data: 75416-52-3(Hazardous Substances Data)

Usage

General Description

6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline, also known as DC-TIQ, is a chemical compound that belongs to the family of isoquinolines. It is a substituted derivative of tetrahydroisoquinoline and is classified as a psychoactive substance. DC-TIQ has been studied for its potential therapeutic effects on mood disorders and addiction. It is also being investigated as a potential treatment for Parkinson's disease. However, DC-TIQ is not approved for medical use and is considered a controlled substance due to its psychoactive properties. Research on this chemical continues to explore its potential applications and effects on the central nervous system.

Upstream product

• 75416-49-8 2-(3,4-dichloro-benzylamino)-ethanol; hydrochloride 
• 1099001-52-1 [2-(3,4-dichloro-phenyl)-ethyl]-carbamic acid ethyl ester 
• 21581-45-3 2-(3,4-dichlorophenyl)ethanamine 
• 115706-19-9 6,7-dichloro-1,2,3,4-tetrahydro-1-oxoisoquinoline 
• 90273-67-9 3-(3,4-dichlorophenyl)propionic acid chloride 
• 115706-18-8 1,2-dichloro-4-(2-isocyanatoethyl)benzene 
• 25173-68-6 3(3,4-dichlorophenyl)propanoic acid 
• 95-76-1 m,p-dichloroaniline 
• 115706-16-6 methyl 2-bromo-3-(3,4-dichlorophenyl)propionate 
• 73075-49-7 6,7-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 73261-87-7 2-acetyl-6,7-dichloro-1,2,3,4-tetrahydroisoquinoline 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 73274-27-8 [1-(3,4-Dichloro-phenyl)-meth-(Z)-ylidene]-(2,2-dimethoxy-ethyl)-amine 
• 444898-81-1 6,7-dichloroisoquinoline 

Downstream Products

• 1150310-59-0 (S)-4-(3-(6,7-dichloro-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide 
• 762199-99-5 6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline 
• 103959-62-2 2-benzoyl-6,7-dichloro-1-cyano-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline 
• 103959-61-1 2-benzoyl-6,7-dichloro-1-cyano-1,2-dihydroisoquinoline 

Relevant articles and documents

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS

The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: I. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines

In a search for inhibitors of epinephrine biosynthesis as potential therapeutic agents, a series of 13 ring-chlorinated 1,2,3,4-tetrahydroisoquinolines was prepared. These compounds were tested initially for their ability to inhibit rabbit adrenal phenylethanolamine N-methyltransferase (PNMT) in vitro. Enzyme-inhibitor dissociation constants, determined for the six most potent members of the series, indicated the following order of decreasing potency: 7,8-Cl2>6,7,8-Cl3>7-Cl~8-Cl>5,6,7,8-Cl4>5,7,8-Cl3. These compounds were subsequently examined for PNMT-inhibiting activity in intact rats and mice. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) was the most potent member of the series both in vitro and in vivo and is currently undergoing clinical investigation.