75426-48-1

Basic information

• Product Name: 3-[4-(3-methylphenyl)piperazin-1-yl]propanenitrile
• CAS NO: 75426-48-1
• Molecular Formula: C₁₄H₁₉N₃
• Molecular Weight: 229.3208
• Mol File: 75426-48-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 413.6°C at 760 mmHg
• Flash Point: 183.3°C
• Density: 1.059g/cm³
• Vapor Pressure: 4.73E-07mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 3-[4-(3-methylphenyl)piperazin-1-yl]propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(3-methylphenyl)piperazin-1-yl]propanenitrile(75426-48-1)
• EPA Substance Registry System: 3-[4-(3-methylphenyl)piperazin-1-yl]propanenitrile(75426-48-1)

Safety Data

• Hazardous Substances Data: 75426-48-1(Hazardous Substances Data)

Usage

Chemical Structure

Piperazine-based compound with a nitrile group

Function

Dopamine D3 receptor antagonist

Affinity

Exhibits high affinity for the dopamine D3 receptor subtype

Research Use

Primarily used in research settings

Potential Therapeutic Applications

Substance abuse treatment
Schizophrenia treatment
Treatment of other psychiatric disorders

Pharmacological Properties

Modulation of dopaminergic neurotransmission

Research Status

Promising results in preclinical studies
Ongoing research for medical applications

Upstream product

• 41186-03-2 1-(3-Methylphenyl)piperazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 61015-48-3 3-(4-m-tolyl-piperazin-1-yl)-propionamide 
• 500294-64-4 3-(4-m-tolyl-piperazino)-propionic acid 
• 79323-03-8 4-(4-Methoxy-phenyl)-1-[3-(4-m-tolyl-piperazin-1-yl)-propyl]-piperidine-2,6-dione 
• 20529-22-0 3-(4-m-tolyl-piperazin-1-yl)-propylamine 

Relevant articles and documents

Synthesis of N-[3-(4-aryl-1-piperazinyl)propyl]-4,4-bis(4-methoxyphenyl)piperidine-2,6-di ones/tetrahydrophthalimides/camphorimides as sedatives

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