75427-06-4Relevant articles and documents
“On Water” Palladium Catalyzed Direct Arylation of 1H‐Indazole and 1H‐7‐Azaindazole
Abbouchi, Abdelmoula El,Akssira, Mohamed,Bousmina, Mostapha,El Kazzouli, Sa?d,Gambouz, Khadija,Guillaumet, Gérald,Nassiri, Sarah,Suzenet, Franck
, (2020)
The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3-aryled 1H-7-azaindazoles via a C3 direct arylation using water as solvent. On water, PPh3 was effective as a ligand along with a lower charge of the catalyst Pd(OAc)2 (5 mol%) at 100 oC, leading to C3-aryled 1H-indazoles or C3-aryled 1H-7-azaindazoles in moderate to good yields.
