75437-13-7Relevant articles and documents
Preparation of pharmaceuticals by hydroformylation. Part III. The synthesis of N-(4-Pyridyl)-3,3-diphenyl-1-aminopropane (Phenpyramine, Milverine)
Marchetti,Sechi,Botteghi,Paganelli
, p. 74 - 76 (2007/10/03)
N-(4-Pyridyl)-3,3-diphenyl-1-aminopropane (1) (Phenpyramine, Milverine), an important amino-pyridine derivative endowed with Muscarinic antagonist activity, is prepared starting from 1,1-diphenylethene using the hydroformylation as key the step in the reaction scheme: the obtained aldehyde was transformed in the desired compound 1 by a three steps reaction sequence; the overall yield was up to 42.8%.