75472-28-5

Basic information

• Product Name: 1-(1,3-benzothiazol-2-yl)-N,N-bis(1,3-benzothiazol-2-ylmethyl)methanamine
• Synonyms: 1,3-Benzothiazol-2-yl-N,N-bis(1,3-benzothiazol-2-ylmethyl)methanamine; N,N,N-Tris(1,3-benzothiazol-2-ylmethyl)amine
• CAS NO: 75472-28-5
• Molecular Formula: C₂₄H₁₈N₄S₃
• Molecular Weight: 458.6215
• Mol File: 75472-28-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 627.2°C at 760 mmHg
• Flash Point: 333.1°C
• Density: 1.442g/cm³
• Vapor Pressure: 1.21E-15mmHg at 25°C
• Refractive Index: 1.801
• CAS DataBase Reference: 1-(1,3-benzothiazol-2-yl)-N,N-bis(1,3-benzothiazol-2-ylmethyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,3-benzothiazol-2-yl)-N,N-bis(1,3-benzothiazol-2-ylmethyl)methanamine(75472-28-5)
• EPA Substance Registry System: 1-(1,3-benzothiazol-2-yl)-N,N-bis(1,3-benzothiazol-2-ylmethyl)methanamine(75472-28-5)

Safety Data

• Hazardous Substances Data: 75472-28-5(Hazardous Substances Data)

Usage

Description

1-(1,3-Benzothiazol-2-yl)-N,N-bis(1,3-benzothiazol-2-ylmethyl)methanamine, commonly known as Antimycin A3, is a naturally occurring compound derived from the bacterium Streptomyces sp. It is characterized by its antimicrobial properties and its ability to inhibit the mitochondrial electron transport chain complex III. This nitrogen-containing heterocyclic compound features benzothiazole rings and an amine group, which contribute to its potential applications in diverse sectors such as medicine, agriculture, and environmental protection.

Uses

Used in Pharmaceutical Applications:
Antimycin A3 is utilized as an antitumor agent, leveraging its capacity to inhibit mitochondrial electron transport and thereby disrupting cancer cell metabolism. It is particularly effective against various types of cancer, including solid tumors.
Used in Agricultural Applications:
As a potent antimicrobial agent, Antimycin A3 is employed in the agricultural industry to combat microbial infections in crops, thereby enhancing crop yield and quality.
Used in Environmental Protection:
Due to its antimicrobial properties, Antimycin A3 is also used in environmental protection applications, such as water treatment and waste management, to control the growth of harmful microorganisms.
Used in Respiratory Disease Treatment:
Antimycin A3 has shown promise as a therapeutic agent for respiratory diseases, potentially offering a new avenue for treatment by targeting the mitochondria in affected cells.

Upstream product

• 139-13-9 nitrilotriacetic acid 
• 137-07-5 2-amino-benzenethiol 
• 7327-60-8 nitrilotriacetonitrile 

Relevant articles and documents

METAL COMPLEXES FOR PROMOTING GROWTH IN A PHOTOSYNTHETIC ORGANISM

A method of promoting growth in a photosynthetic organism comprising treating the photosynthetic organism with a metal complex or a precursor thereof, wherein the metal complex comprises a metal selected from the group consisting of zinc (Zn), cobalt (Co), copper (Cu), nickel (Ni) and iron (Fe), and a ligand, which is a bidentate or tridentate ligand. Metal complexes and their ligands are also described.

LIGANDS FOR COPPER-CATALYZED AZIDE-ALKYNE CYCLOADDITION REACTIONS

Ligands useful for promoting copper-catalyzed azide-alkyne cycloaddition reactions comprise a compound represented by structural Formula (I) as described in the specification, wherein in Formula (I) Z1 is a nitrogen-containing heterocyclic group or a group represented by the formula : Y1-(CH2)c-Y2-(CH2)d-Y3-CH2-N(CH2Z4)(CH2Z5), where Y1 is -E1-C(O)O-, -E1-C(O)NH-, -E1-, or a covalent bond; Y2 is a covalent bond, -CH=CH-, or a 1,4-(1,2,3-triazolyl) group; Y3 is -OC(O)-E2-, -NHC(O)-E2-, -E2-, or a covalent bond; each of E1 and E2 is a benzimidazolyl group attached at the 1 and 2 positions; each of c and d is independently 1, 2, 3, 4, or 5; each of Z2, Z3, Z4 and Z5 is a nitrogen-containing heterocyclic group including a substituent X1 and optionally including a substituent (CH2)n-R1, and Y1, Y2, Y3, X1, R1, c, d and n are each as defined in the specification.

Complexes of substituted benzothiazoles. 2. Copper(II) complexes of the 'tripod' ligand tris(2-benzothiazolylmethyl)amine

A series of copper(II) complexes of the title ligand are reported which exhibit both five-coordinate trigonal bipyramidal and pseudo-octahedral stereochemistries.Mixed stereochemistry complexes 2 (X=Cl, Br), 2*CH3CN, and the complexes BPh4(CH3CN)2*0.5H2O, NO3*0.5H2O, contain trigonal bipyramidal cations while six-coordinate structure are implicated in the systems *H2O and (ClO4)2*MeOH*H2O.The molecular structure of NO3*0.5H2O has been determined by single crystal X-ray diffractometry.The crystal is monoclinic and belongs to the space group C2/c with Z=8, a=24.254(3), b=14.107(2), c=16.329(2) Angstroem and β=105.94(1) degree.The complex adopts a distorted trigonal bipyramidal structure (no axial symmetry) with the ligand coordinating in a 'tripod' fashion as an N4 donor.The fifth ligand is a monodentate nitrate.The mean Cu-N distance is 2.07(3) Angstroem and the Cu-O distance is 1.938(3) Angstroem.A second nitrate oxygen atom is close to the copper centre (Cu-O distance 2.783(4) Angstroem) and may represent a weakly bound sixth ligand.Both infrared and electronic spectral data support the presence of a sixth ligand.Both infrared and electronic spectral data support the presence of a sixth ligand.