75473-09-5

Basic information

• Product Name: 2,3-Dichlorobenzoylacetonitrile
• Synonyms: 2,3-Dichlorobenzoylacetonitrile
• CAS NO: 75473-09-5
• Molecular Formula: C₉H₅Cl₂NO
• Molecular Weight: 214.05
• Mol File: 75473-09-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 65-66 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 351.5 °C at 760 mmHg
• Flash Point: 166.4 °C
• Appearance: /
• Density: 1.383 g/cm³
• Vapor Pressure: 4.1E-05mmHg at 25°C
• Refractive Index: 1.567
• PKA: 5.75±0.10(Predicted)
• CAS DataBase Reference: 2,3-Dichlorobenzoylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichlorobenzoylacetonitrile(75473-09-5)
• EPA Substance Registry System: 2,3-Dichlorobenzoylacetonitrile(75473-09-5)

Safety Data

• Hazardous Substances Data: 75473-09-5(Hazardous Substances Data)

Usage

General Description

2,3-Dichlorobenzoylacetonitrile is a synthetically produced chemical compound which has applications in the field of organic chemistry. Its structure is characterized by a benzene ring, chlorinated at the 2 and 3 positions, and attached to a nitrile group via an acetyl linkage. It is used as a reagent, particularly in the synthesis of various other complex organic compounds. The chemical is solid in nature and has a molecular weight of about 223.04 g/mol. Special precautions must be taken while handling as it may be harmful if swallowed, inhaled or in contact with the skin, and can cause eye irritation.

InChI:InChI=1/C9H5Cl2NO/c10-7-3-1-2-6(9(7)11)8(13)4-5-12/h1-3H,4H2

Upstream product

• 2905-54-6 2,3-Dichlorobenzoic acid methyl ester 
• 6574-97-6 2,3-dichlorobenzonitrile 
• 75473-06-2 3-(2,3-Dichloro-phenyl)-3-imino-propionitrile 

Downstream Products

• 75473-15-3 (2-Amino-thiophen-3-yl)-(2,3-dichloro-phenyl)-methanone 
• 75473-49-3 5-(2,3-Dichloro-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-56-2 7-Chloro-5-(2,3-dichloro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-48-2 7-Chloro-5-(2,3-dichloro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-25-5 N-[3-(2,3-Dichloro-benzoyl)-thiophen-2-yl]-2-iodo-acetamide 
• 75473-20-0 2-Chloro-N-[3-(2,3-dichloro-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-29-9 2-Amino-N-[3-(2,3-dichloro-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-52-8 5-(2,3-Dichloro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-35-7 5-(2,3-Dichloro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 

Relevant articles and documents

Pharmacologically active CNS compounds

The invention relates to compounds of formula (I) and salts thereof wherein R1 and R2 are the same or different and are each selected from hydroxy, or a group NR9R10 wherein R9 and R10 are each hydrogen, alkyl, aryl, arylalkyl or together with the nitrogen atom to which they are attached form a ring, optionally containing a further heteroatom and optionally further substituted by alkyl, aryl or arylalkyl;, R3 is selected from hydrogen, haloalkyl, alkyl and halo, R4 to R8 are the same or different, and are each selected from hydrogen, halo, nitro, amino, sulphonamido or alkylsulphonylamino;, or R4 and R5 or R5 and R6 may together form a carbocyclic ring;, with the proviso that at least one of R4 to R8 is other than hydrogen. The compounds may be used for the treatment or prophylaxis of a neurodegenerative or other neurological disorder of the CNS, the aetiology of which includes excessive release of the neurotransmitter glutamate.