755736-58-4

Basic information

• Product Name: (E)-7-[4-(4-Fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid
• CAS NO: 755736-58-4
• Molecular Weight: 423.484
• Mol File: 755736-58-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-7-[4-(4-Fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-7-[4-(4-Fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid(755736-58-4)
• EPA Substance Registry System: (E)-7-[4-(4-Fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid(755736-58-4)

Safety Data

• Hazardous Substances Data: 755736-58-4(Hazardous Substances Data)

Upstream product

• 121659-65-2 4-(4'-fluorophenyl)-3-hydroxymethyl-2-(1'-methylethyl)-quinoline 
• 121659-66-3 4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinecarboxaldehyde 
• 130954-90-4 methyl (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenoate 
• 121659-68-5 (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenal 
• 130954-91-5 (E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propen-1-ol 
• 3800-06-4 2-amino-4'-fluorobenzophenone 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 121678-81-7 (E)-7-[4-(4-Fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester 

Downstream Products

• 118312-79-1 (4S,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one 
• 118312-79-1 <4α,6β(E)>-6-<2-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>ethenyl>tetrahydro-4-hydroxy-2H-pyran-2-one 

Relevant articles and documents

Inhibitors of Cholesterol Biosynthesis. 4. trans-6-tetrahydro-4-hydroxy-2H-pyran-2-ones, a Novel Series of HMG-CoA Reductase Inhibitors

A series of substituted quinoline mevalonolactones were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase both in vitro and (cholesterol biosynthesis) in vivo.Since previous studies suggested that the 4-(4-fluorophenyl) and 2-(1-methylethyl) substituents afforded optimum potency, attention was focused on variations at position 6 of the quinoline ring.Biological evaluation of a small number of analogues bearing a variety of 6-substituents showed that modification at this position had little effect on potency.Several compounds (8b, 8e, and 11) were identified that showed comparable potency to compaction and mevinolin in both the in vitro and in vivo assays.