75634-04-7

Basic information

• Product Name: 2-Chloro-4-(4-methoxyphenyl)pyrimidine
• Synonyms: 2-Chloro-4-(4-methoxyphenyl)pyrimidine
• CAS NO: 75634-04-7
• Molecular Formula: C₁₁H₉ClN₂O
• Molecular Weight: 220.65
• Product Categories: blocks
• Mol File: 75634-04-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 401.6ºC at 760 mmHg
• Flash Point: 196.7ºC
• Appearance: /
• Density: 1.245g/cm3
• Vapor Pressure: 2.71E-06mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Chloro-4-(4-methoxyphenyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-(4-methoxyphenyl)pyrimidine(75634-04-7)
• EPA Substance Registry System: 2-Chloro-4-(4-methoxyphenyl)pyrimidine(75634-04-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 75634-04-7(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(4-methoxyphenyl)pyrimidine is a chemical compound with the molecular formula C11H9ClN2O. It is a pyrimidine derivative with a chlorine atom and a 4-methoxyphenyl group attached to the 2 and 4 positions, respectively. 2-Chloro-4-(4-methoxyphenyl)pyrimidine has potential applications in pharmaceutical and agrochemical industries, as it can be used as a building block in the synthesis of various biologically active compounds. Its structure and properties make it a valuable intermediate in the production of pharmaceuticals and pesticides. Additionally, it is important to handle this compound with care, as it may have hazardous effects if not properly handled.

InChI:InChI=1/C11H9ClN2O/c1-15-9-4-2-8(3-5-9)10-6-7-13-11(12)14-10/h2-7H,1H3

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 82303-13-7 (4-methoxyphenyl)zinc(II) bromide 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 682793-43-7 4-(4-methoxyphenyl)-2-(4-methylpiperazino)pyrimidine 
• 1236002-91-7 N-(4-(4-methoxyphenyl)pyrimidin-2-yl)oxazol-2-amine 
• 1236002-87-1 4-(4-methoxyphenyl)-N-(pyrazin-2-yl)pyrimidin-2-amine 
• 1236002-81-5 4-(4-methoxyphenyl)-N-(4-methylpyridin-2-yl)pyrimidin-2-amine 
• 1236002-84-8 5-ethyl-N-(4-(4-methoxyphenyl)pyrimidin-2-yl)-1,3,4-thiadiazol-2-amine 
• 1236002-96-2 4,4'-bis(4-methoxyphenyl)-2,2'-bipyrimidine 
• 1236002-93-9 1-benzyl-N-(4-(4-methoxyphenyl)pyrimidin-2-yl)-1H-benzo[d]imidazol-2-amine 
• 1253396-38-1 2-[(E)-hept-1-enyl]-4-(4-methoxyphenyl)pyrimidine 

Relevant articles and documents

Synthesis and evaluation of the NSCLC anti-cancer activity and physical properties of 4-aryl-N-phenylpyrimidin-2-amines

Reported herein are efforts to profile 4-aryl-N-phenylpyrimidin-2-amines in terms of their anti-cancer activity towards non small-cell lung carcinoma (NSCLC) cells. We have synthesized new 4-aryl-N-phenylpyrimidin-2-amines and assessed them in terms of their cytotoxicity (A549, NCI-H187, MCF7, Vero & KB) and physicochemical properties (logD7.4 and solubility). 13f and 13c demonstrated potent anti-cancer activity in A549 cells (0.2 μM), compared to 0.4 μM for the NSCLC drug Doxorubicin. 13f also displayed low experimental logD7.4 (2.9) and the best solubility (～40 μM). Compounds 13b and 13d showed the best balance of A549 anti-cancer activity and selectivity. 13g showed good activity and selectivity comparable with the anti-cancer drug Doxorubicin.

Convenient preparation of 4-aryl-2-(heteroarylamino)pyrimidines and 4-anilino-2-(heteroarylamino)pyrimidines

4-Aryl-2-anilinopyrimidines and 2,4-dianilinopyrimidines are privileged structures found in many drug-like molecules and biologically active compounds. A method for the quick assembly of novel 4-aryl- and 4-anilino-2-(heteroarylamino)pyrimidines via Buchwald-Hartwig N-arylations at elevated temperatures under sealed tube conditions is reported. This method's convenience and practicality is demonstrated through the preparation of several novel non-nucleoside reverse transcriptase inhibitor (NNRTI) analogues.

Synthesis of 4-substituted 2-(4-methylpiperazino)pyrimidines and quinazoline analogs as serotonin 5-HT2A receptor ligands

(Chemical Equation Presented) The addition reaction of lithium reagents to the 4 position of 2-chloropyrimidine or 2-chloroquinazoline followed by oxidation of the resultant dihydro intermediate product is a powerful tool for the synthesis of 4-substitute