75698-43-0

Basic information

• Product Name: ethyl 2-(4-methoxyphenyl)-4,6-dioxocyclohexanecarboxylate
• Synonyms: ethyl 2-(4-methoxyphenyl)-4,6-dioxocyclohexanecarboxylate
• CAS NO: 75698-43-0
• Molecular Formula: C₁₆H₁₈O₅
• Molecular Weight: 290.31112
• Mol File: 75698-43-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(4-methoxyphenyl)-4,6-dioxocyclohexanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-methoxyphenyl)-4,6-dioxocyclohexanecarboxylate(75698-43-0)
• EPA Substance Registry System: ethyl 2-(4-methoxyphenyl)-4,6-dioxocyclohexanecarboxylate(75698-43-0)

Safety Data

• Hazardous Substances Data: 75698-43-0(Hazardous Substances Data)

Upstream product

• 105-53-3 diethyl malonate 
• 3815-30-3 4-(4-methoxyphenyl)-3-buten-2-one 
• 943-88-4 4-(p-methoxyphenyl)-3-butene-2-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 24393-56-4 ethyl p-methoxycinnamate 
• 141-97-9 ethyl acetoacetate 
• 141-52-6 sodium ethanolate 

Downstream Products

• 1774-12-5 5-(4-methoxyphenyl)-1,3-cyclohexanedione 

Relevant articles and documents

Construction of Multiple-Substituted Chiral Cyclohexanes through Hydrogenative Desymmetrization of 2,2,5-Trisubstituted 1,3-Cyclohexanediones

The construction of chiral multiple-substituted cyclohexanes motifs is a challenging topic in organic synthesis. By the combination of desymmetrization and remote stereocontrol, a ruthenium-catalyzed transfer hydrogenative desymmetrization of 2,2,5-trisubstituted 1,3-cyclohexanediones has been successfully developed for the construction of chiral multiple-substituted cyclohexanes with high enantioselectivity and diastereoselectivity. When an ester group was introduced to the two-position, a hydrogenative desymmetrization/transesterification cascade occurred, affording the bicyclic lactones bearing three stereocenters, including two discrete stereocenters and one quaternary stereogenic center, with high enantioselectivity. The products are the multiple-substituted chiral cyclohexanes bearing the hydroxyl and carbonyl functional groups, which provide a new opportunity for further precise elaboration.